Surface Logix, Inc.

Stewart Campbell

David C Duffy

Olivier Schueller

Paul Sweetnam

Gregory Kirk

Alessandra Bartolozzi

Hope Foudoulakis

Melina Amber Agosto

Enoch Kim

Siya Ram

Brian Kirk

Hemalatha Seshadri

Yingfei Yang

Michael J Grogan

Emanuele Ostuni

Steven A Kates

The present invention relates to inhibitors of ROCK1 and ROCK2 and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and or ROCK2 that are useful for the treatment of disease.

Pharmacokinetically improved compounds

The present invention relates to compounds which are inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (Apo B) secretion. These compounds can be useful for the prevention and treatment of various diseases, particularly atherosclerosis and its clinical sequelae, for lowering serum lipids, and related ailments. The invention further relates to pharmaceutical compositions comprising the compounds and to methods of treating diseases, such as hypertriglyceridemia, hyperchylomicronemia, atherosclerosis, obesity, and related conditions using the compounds. A method for decreasing apolipoprotein B (apo B) secretion is also provided.

Inhibitors of microsomal triglyceride transfer protein and apo-B secretion

Rho-kinase inhibitors and method of preparation

A compound of formula A having improved non-specific binding characteristics and pharmacokinetic properties is provided: or a pharmaceutically acceptable salt, stereoisomer, or hydrate thereof.

Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material.

Peelable and resealable devices for arraying materials

Peelable and resealable devices for biochemical assays

Methods for processing biological materials using peelable and resealable devices

Methods of arraying biological materials using peelable and resealable devices

Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates thc performance of processes on and/or detection of the immobilized material.

Methods of detecting immobilized biomolecules

Methods of measuring enzyme activity using peelable and resealable devices

Growing community of inventors

Framingham, MA, United States of America

Stewart Campbell