Advanced Cardiovascular Systems, Inc.

Steven Z Wu

Syed F A Hossainy

Sameer Harish

Deborra Sanders-Millare

Judy A Guruwaiya

Li Fu Chen

Daryush Mirzaee

Daniel A Castro

Kurt W Scheinpflug

Kevin L Woolbright

Deborra Sanders Millare

Debbie Sanders-Millare

Syed F Hossainy

Charlene Chen

Stephen D Pacetti

Syed Faiyaz Ahmed Hossainy

Wouter Erik Roorda

Anthony S Andreacchi

Manish Gada

Vinayak Bhat

Shamim M Malik

Ryan John Santos

Syed Fa Hossainy

Brandon James Yoe

Steven L Mouw

A drug-loaded microparticle is applied to a medical device for subsequent application to biological tissues. A method of formulating a drug-loaded microparticle and applying it to the surface of a medical device, such as a stent, is disclosed. The drug-loaded microparticle is formulated by combining a drug with various chemical solutions. Specified sizes of the microparticles and amounts of drug(s) contained within the microparticles may be varied by altering the proportions of the chemicals/solutions. In addition to various drugs, therapeutic substances and radioactive isotopes may also be loaded into the microparticles. The drug-loaded microparticle are suspended in a polymer solution forming a polymer matrix. The polymer matrix may be applied to the entire surface or only selected portions of the medical device via dipping, spraying or combinations thereof.

Microparticle coated medical device

Methods of forming microparticle coated medical device

The invention provides bioactive compositions and methods of delivery for ameliorating a vascular diseased state, particularly for the management of stenosis or restenosis following a vascular trauma or disease.

Medicated stents for the treatment of vascular disease

A patterned coating on a prosthesis, for example a stent, and a method for forming the coating are disclosed Additionally, an apparatus for forming the patterned coating is disclosed.

Apparatus and method for depositing a coating onto a surface of a prosthesis

An implantable medical device, such as a stent or graft, having asperities on a designated region of its outer surface is disclosed. The asperities can serve to improve retention of one or more layers of a coating on the device and to increase the amount of coating that can be carried by the device. The asperities can be formed by using a stream of pressurized grit to roughen the surface. The asperities can also be formed by removing material from the outer surface, for example, by chemical etching with or without a patterned mask. Alternatively, the asperities can be formed by adding material to the outer surface, for example, by welding powder particles to the outer surface or sputtering.

Method of making an implantable medical device

A patterned coating on a prosthesis, for example a stent, and a method for forming the coating are disclosed. Additionally, an apparatus for forming the patterned coating is disclosed.

Method for depositing a coating onto a surface of a prosthesis

A composition for coating an implantable prosthesis, such as a stent is disclosed. A method of forming the composition is also disclosed.

Composition for coating an implantable prosthesis

An apparatus and associated method for delivering a therapeutic substance to a vascular lumen, using an implantable prosthesis, such as a stent, which has grooves or trenches formed thereon. The grooves are formed on specific regions of the stent struts to increase the flexibility of the stent. The grooves also provide a therapeutic material carrying capability for treating intravascular ailments, such as instent restenosis and thrombosis. The therapeutic material loading of the grooves can be accomplished in several ways. For example, a pure therapeutic material or a pre-mixed material with a polymer solution, which enhances the adhesion properties of the material, may be deposited directly in to the grooves using conventional spray or modified dip techniques. In another example, a microextruded monofilament therapeutic material can be wound about the stent, such that the monofilament becomes embedded in the grooves.

Implantable drug delivery prosthesis

Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.

Coating for implantable devices and a method of forming the same

Surface features of an implantable medical device

A coating for a prosthesis, for example a stent, and a composition for forming the coating is disclosed. The coating can serve as a primer, allowing substances, such as polymers, to be effectively secured by the prosthesis. Alternatively, the coating can serve as a reservoir, allowing for the local and sustained release of a therapeutic substance to biological tissues. The composition can be formed from an ethylene vinyl alcohol copolymer and a dimethylsulfoxide solvent, with or without a therapeutic substance. Alternatively, the composition can be formed from an ethylene vinyl alcohol copolymer, a dimethylsulfoxide solvent, and a wetting fluid, with or without a therapeutic substance. The composition is applied to a surface of the prosthesis and essentially all of the dimethylsulfoxide solvent or dimethylsulfoxide solvent/wetting fluid is removed or allowed to evaporate to form the coating.

Biocompatible coating for a prosthesis and a method of forming the same

A stent or intraductal medical device manufactured from a tubular member having an inner tube tightly fitted into an outer tube is provided. Microdepots may be formed on the outer surface of the inner tube, and may contain radioactive, radiopaque or therapeutic substances. A method for manufacturing such a medical device or stent is also described. The material to be deposited on the inner tube may be deposited on the inner tube by dipping or immersion, or the material may be applied to the inner tube using micro-injection or electrodeposition. The material to be deposited may be applied to cavities or microdepots formed in the outer surface of the inner tube. Excess material may be removed from the inner tube by centrifugation or shaking, and the material to be deposited may be heated to bond the material to the surface of the microdepots on the inner tube.

Double tube stent

A stent or intraductal medical device is provided having radiopaque marker material deposited on the surface of the stent or medical device to assist visualization of the device during implantation. A method for depositing a radiopaque material on an implantable medical device such as a stent is also described. The radiopaque material may be deposited on the medical device by dipping or immersion, or the radiopaque material may be applied to the device using micro-injection or electrodeposition. The radiopaque material may coat the entire surface of the stent, or only a portion of the stent, or it may be applied to cavities or microdepots formed in the outer surface of the medical device. Excess radiopaque material may be removed from the device by centrifugation or shaking, and the radiopaque material may be heated to bond the material to the surface of the device.

Growing community of inventors

Santa Clara, CA, United States of America

Steven Z Wu