Biotech Australia Pty Ltd

Steven William Westwood

Gregory John Russell-Jones

Bernard V McInerney

Alison R Gould

The invention describes complexes between VB,analogues and either GCSF or EPO that retain both significant affinity for intrinsic factor (IF) in the VB,portion of the complex and significant bioactivity of the GCSF or EPO portion of the complex. The invention also concerns a process for the synthesis of these complexes. This is achieved at least in part, by using a spacer compound, which is linked covalantly between the VB,portion and the GCSF or EPO. The complexes preferably have the formula

Vitamin B12 conjugates with gcsf, analogues thereof and pharmaceutical compositions

Oral delivery systems for microparticles

The invention describes complexes between VB.sub.12 analogues and either GCSF or EPO that retain both significant affinity for intrinsic factor (IF) in the VB.sub.12 portion of the complex and significant bioactivity of the GCSF or EPO portion of the complex. The invention also concerns a process for the synthesis of these complexes. This is achieved at least in part, by using a spacer compound, which is linked covalantly between the VB.sub.12 portion and the GCSF or EPO. The complexes preferably have the formula

Vitamin B.sub.12 mediated oral delivery systems for GCSF

Vitamin B12 conjugates with EPO, analogues thereof and pharmaceutical

The invention relates to the oral delivery of peptide and protein pharmaceuticals using the vitamin B.sub.12 (VB.sub.12) uptake system, with the delivery being amplified using polymers. More particularly, the invention concerns a complex having the general formula:

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Ashfield, Australia

Steven William Westwood