Genentech, Inc.

Life Technologies Corporation

Danisco US Inc.

Genetech, Inc.

Steven W Sherwood

Austin L Gurney

William I Wood

Audrey Goddard

Paul J Godowski

Victoria Smith

Colin K Watanabe

Daniel Tumas

Timothy Andrew Stewart

Luc Roland Desnoyers

Kevin P Baker

Ellen Filvaroff

Zemin Zhang

Mary E Gerritsen

Wei-Qiang Gao

Maureen H Beresini

Laura Deforge

Aldrich Lau

Huan L Phan

Joon Mo Yang

Hans Fuernkranz

The present invention provides method and compositions for detecting target molecules present on cells and tissues. In particular, the methods involve adding primary antibodies such as scFv-targeted lactamase that are directed against a target of interest (e.g., cancer markers) to a tissue sample, followed by adding a lactam-containing compound and finally a lactamase reporter system. In some preferred embodiments, the lactamase reporters are fluorescent reporters that bind to the test tissue. In some particularly preferred embodiments, the test tissue contains at least once cancer cell and/or at least one cancer-associated marker.

Methods for detecting targets

A method for sorting cells in a biological sample comprising a first type of cells and a second type of cells may comprise introducing the biological sample into a chamber comprising a first surface and a second surface, wherein the first surface is associated with a transparent electrode and the second surface is associated with a photoconductive portion of an electrode. The method may further comprise moving incident light and the photoconductive portion relative to one another so as to illuminate regions of the photoconductive portion and modulate an electric field in the chamber in proximity to the illuminated regions. The method may further comprise separating the first type of cells from the second type of cells in the chamber via dielectrophoretic movement of the first type of cells and the second type of cells caused by the modulated electric field, wherein a dielectrophoretic characteristic of at least one of the first type of cells and the second type of cells has been modified.

Devices and methods for optoelectronic manipulation of small particles

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

PRO350 antibodies

The present invention is directed to novel PRO1475 polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the PRO1475 polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the PRO1475 polypeptides of the present invention and to methods for producing the PRO1475 polypeptides of the present invention.

Growing community of inventors

Los Altos, CA, United States of America

Steven W Sherwood