Sepracor, Inc.

Steven W Jones

Mark G Currie

Charles M Zepp

Kerry Leigh Spear

Chrisantha Hugh Senanayake

Michele L R Heffernan

Seth C Hopkins

Robert J Foglesong

Mark A Varney

Mustapha Soukri

Zhi-Hiu Lu

This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. The invention also provides methods for the treatment and prevention of neurological disorders, such as neuropsychiatric and neurodegenerative diseases, as well as pain, ataxia and convulsion. The compounds of the invention have the general structure: wherein A is NH or S. Q is a member selected from CRand N. X and Y are members independently selected from O, S, CR, N and NH. R, Rand Rare members independently selected from H and F, provided that at least one member selected from R, Rand Ris F. Ris a member selected from OXand OH, wherein Xis a positive ion, which is a member selected from inorganic positive ions and organic positive ions.

Fluoro-substituted inhibitors of D-amino acid oxidase

Compounds are disclosed of the formula in which Ris Cto Chydrocarbon or the residue of misoprostol. The compounds are useful for treating rhinitis and asthma, particularly by inhalation, and for treating inflammation, particularly by local or topical administration.

Fatty acid modified forms of glucocorticoids

The invention encompasses methods of using racemic and enantiomerically pure norfluoxetine, as well as pharmaceutical compositions, pharmaceutical unit dosage forms, and kits comprising racemic and enantiomerically pure norfluoxetine. In particular, the invention encompasses a method of inhibiting or reducing the production of PGE. The invention further encompasses a method of treating or preventing inflammation in a patient, as well as a method of treating or preventing a disease or disorder such as, but not limited to, autoimmune diseases, arthritis, neurologic diseases, inflammatory diseases, fibromyalgia, pain resulting from inflammation, neuropathic pain, and cancer.

Methods of using norfluoxetine

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Milford, MA, United States of America

Steven W Jones