University of California

Steven W Hetts

Anand S Patel

Mark W Wilson

Xi Chelsea Chen

Nitash Balsara

Albert K Chin

Prasheel V Lillaney

Aaron D Losey

Andre M Cote

Jeffrey Yang

Bridget F Kilbride

Caroline D Jordan

Bradford R H Thorne

Marc C Mabray

Sravani Kondapavulur

Vitaliy Lvovich Rayz

In vivo positionable filtration devices are provided that filter one or more therapeutic agents in blood flowing in a blood vessel. The filtration devices include an elongated member and a filtering component coupled to the elongated member. The elongated member and the filtering component are dimensioned for positioning within the blood vessel. Further, the filtering component includes a filtration material to filter the one or more therapeutic agents from the blood. Methods of in vivo filtration of the one or more therapeutic agents are also provided. The methods include positioning a filtration device of the filtration devices in the blood vessel, and administering a therapeutic agent of the one or more therapeutic agents upstream from a target tissue site to direct flow of the therapeutic agent to the target tissue site and then to the filtration device. The filtration device is positioned downstream from the target tissue site.

In vivo positionable filtration devices and methods related thereto

In vivo and ex vivo positionable filtration devices are provided that are functionalized to bind one or more therapeutic agents in blood flowing in a blood vessel.

Filtration devices and methods related thereto

In vivo positionable filtration devices are provided that filter one or more therapeutic agents in blood flowing in a blood vessel. The filtration devices include an elongated member and a filtering component coupled to the elongated member. The elongated member and the filtering component are dimensioned for positioning within the blood vessel of a human or non-human animal. Further, the filtering component includes a filtration material to filter the one or more therapeutic agents from the blood. Methods of in vivo filtration of the one or more therapeutic agents are also provided. The methods include positioning a filtration device in the blood vessel of a body of the human or non-human animal, and administering a therapeutic agent upstream from a target tissue site to direct flow of the therapeutic agent to the target tissue site and then to the filtration device. The filtration device is positioned downstream from the target tissue site.

In vivo and ex vivo positionable magnetic filtration devices are provided that magnetically filter one or more therapeutic agents conjugated to a magnetic particle in blood flowing in a blood vessel.

Magnetic filtration devices and methods related thereto

Described herein is a porous copolymer membrane composed of poly(styrene sulfonate)-block-polyethylene-block-poly(styrenesulfonate) for use in the absorption of doxorubicin, and a chemofiltration catheter incorporating the membrane for use in transarterial chemoembolization.

Copolymer membrane for high-dose chemotherapy delivery during transarterial chemoembolization

Growing community of inventors

Hillsborough, CA, United States of America

Steven W Hetts