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Daihatsu Motor Company, Ltd.

Cambridge University Technical Services Limited

Hokko Chemical Industry Co., Ltd.

Pentraxin Therapeutics Limited

Reaxa Limited

Steven Victor Ley

Hirohisa Tanaka

Derek H Barton

Chandrashekar Ramarao

Martin D Smith

Mark Brian Pepys

Ian Malcolm Shirley

Kimiyoshi Kaneko

Stephen Christopher Smith

Clive A Meerholz

David Joszef Tapolczay

Angus John Morrison

Vittorio Bellotti

Simon Kolstoe

Martin Smith

Sophie Lohmann

Steven P Andrews

J Paul Attfield

Antonia F Stepan

David J Lester

A microencapsulated catalyst is prepared by dissolving or dispersing a catalyst in a first phase (for example an organic phase), dispersing the first phase in a second, continuous phase (for example an aqueous phase) to form an emulsion, reacting one or more microcapsule wall-forming materials at the interface between the dispersed first phase and the continuous second phase to form a microcapsule polymer shell encapsulating the dispersed first phase core and optionally recovering the microcapsules from the continuous phase. The catalyst is preferably a transition metal catalyst and the encapsulated catalyst may be used for conventional catalysed reactions. The encapsulated catalyst may recovered from the reaction medium and re-cycled.

Microencapsulated catalyst methods of preparation and method of use thereof

The present invention relates to compounds of formula (I) for stabilizing the tetrameric form of transthyretin, compounds for use in the treatment or prevention of amyloidosis, and agents and medicaments comprising such compounds. wherein X, Y, R, R, R, R, m, n, p, q, and the linker are as defined herein.

Compound and use thereof in the treatment of amyloidosis

To provide a catalyst for synthesis reaction which can achieve good yield in the Sonogashira reaction and also can be recovered after the reaction, and a method for synthesizing a compound in which the catalyst for synthesis reaction is used, a perovskite-type composite oxide containing palladium is used as the catalyst for synthesis reaction in the Sonogashira reaction represented by the following reaction scheme (1):R&#x2014;X+HC&#x2261;CR&#x2192;RC&#x2261;CR&#x2003;&#x2003;(1)

Method for synthesizing compound and catalyst for synthesis reaction

A catalyst for synthesis reaction that can allow the cross coupling reaction at an improved yield, and yet can be collected after used for the reaction and recycled, and a synthesizing method for a compound using the same catalyst for synthesis reaction. In the Suzuki cross-couplings given by the following reaction formula (15), palladium containing perovskite-like composite oxide is used as a catalyst for synthesis reaction: 

Synthesizing method for compound, and catalyst for synthesis reaction

The present invention relates to the use of telluroxides as mild and selective oxidizing agents serving to oxidize certain functions, notably &gt;C.dbd.S groups, in the presence of other relatively easily oxidized functions which remain unaffected; telluroxides of interest as oxidizing agents include, for example, compounds of the formula: ##STR1## wherein R and R.sup.1, which may be the same or different, each represent an optionally substituted aryl or heterocyclic group; or R and R.sup.1 together with the tellurium atom therebetween represent a heterocyclic ring, which may contain one or more further heteroatoms, and which may carry substituents and/or fused aromatic rings.

Oxidation process using tellurium oxide catalysts

.alpha.,.beta.-Unsaturated aldehydes and ketones are prepared by reaction of an arylseleninic anhydride with an aldehyde or ketone having at least one hydrogen atom in the .alpha.-position which is or can be in the syn-configuration with respect to at least one hydrogen atom in the said .beta.-position. The ketones used as starting material especially include perhydrophenanthrene ketones such as steroid ketones and the arylseleninic anhydride used may for example be benzeneseleninic anhydride.

Chemical processes

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Cambridge, United Kingdom

Steven Victor Ley