Kemin Pharma B.v.b.a.

Kemin Pharma Europe B.v.b.a.

Steven Van Hoof

Benedikt J Sas

Johan Van Hemel

Eric Peys

Johan Van Der Eycken

Jan Vandenkerckhove

The synthesis and study of biological activity of a series of new molecules with potential antimicrobial activity are described. The molecules are bicyclic carbohydrates, based on furanose sugars. Their antimicrobial activity against viruses is demonstrated, next to cytostatic effects. Significantly, a high and selective activity against Cytomegalovirus was observed.

Furanose-type bicyclic carbohydrates with biological activity

Novel bicyclic carbohydrate compounds are effective for the prophylaxis and treatment of diseases caused by infections of the alphaherpesvirinae HSV-1 and HSV-2. The invention includes the compound wherein X, X, and Xare selected from the group consisting of O, N, and S; wherein Yand Yare selected from the group consisting of O, N, and S; and wherein Z is selected from the group consisting of F, Cl, and Br, as well as analogs, prodrugs and pharmaceutically acceptable salts thereof, together with pharmaceutical compositions for the prophylaxis and treatment of diseases caused by infections of alphaherpesvirinae.

Bicyclic carbohydrates as antiviral bioactives for the treatment of infections caused by the alphaherpesvirinae HSV-1 and HSV-2

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Genk, Belgium

Steven Van Hoof