Bristol-myers Squibb Compnay

Steven V O'Neil

Karnail S Atwal

Saleem Ahmad

David S Weinstein

Shung C Wu

Khehyong Ngu

Sundeep Dugar

Heterocyclic are provided which are sodium/proton exchange (NHE) inhibitors which have the structure wherein n is 1 to 5; X is N or C&#x2014;Rwherein Ris H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl or heteroaryl; Z is a heteroaryl group, R, R, Rand Rare as defined herein, and where X is N, Ris preferably aryl or heteroaryl, and are useful as antianginal and cardioprotective agents. In addition, a method is provided for preventing or treating angina pectoris, cardiac dysfunction, myocardial necrosis, and arrhythmia employing the above heterocyclic derivatives.

Heterocyclic sodium/proton exchange inhibitors and method

Heterocyclic are provided which are sodium/proton exchange (NHE) inhibitors which have the structurewherein n is 1 to 5; X is N or C&#x2014;Rwherein Ris H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl or heteroaryl; Z is a heteroaryl gorup, R, R, Rand Rare as defined herein, and where X is N. Ris preferably aryl or heteroaryl, and are useful as antianginal and cardioprotective agents. In addition, a method is provided for preventing or treating angina pectoris, cardiac dysfunction, myocardial necrosis, and arrhythmia employing the above heterocyclic derivatives.

Bicyclic acyl guanidine sodium/proton exchange inhibitors and method

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Newtown, PA, United States of America

Steven V O'Neil