University of Texas System

Steven Siqing Wang

Glen A Evans

Jia Li

Liying Huang

Edward D Esplin

The present invention identifies the PPP2R1B gene, as a human tumor suppressor gene. Sequencing of the PPP2R1B revealed that the gene is located on human chromosome 11q22-24 and that gene were mutated in tumors and tumor cell lines, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in lung, colon, breast and cervical cancer cells. Methods for diagnosing and treating cancers related to this tumor suppressor also are disclosed.

Growing community of inventors

The Woodlands, TX, United States of America

Steven Siqing Wang