The United States of America, As Represented by the Secretary, Department of Health and Human Services

Biomed Valley Discoveries, Inc.

The United States of America As Represented by the Department of Health

Steven Seaman

Dimiter Stanchev Dimitrov

Zhongyu Zhu

Saurabh Saha

Dean Welsch

Xiaoyan Michelle Zhang

Bradley St Croix

Gary DeCrescenzo

Brad St Croix

Gary A Decrescenzo

Polypeptides and proteins that specifically bind to and immunologically recognize CD276 are disclosed. Chimeric antigen receptors (CARs), anti-CD276 binding moieties, nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, and conjugates relating to the polypeptides and proteins are also disclosed. Methods of detecting the presence of (a) cancer or (b) tumor vasculature in a mammal and methods of (a) treating or preventing cancer or (b) reducing tumor vasculature in a mammal are also disclosed.

Anti-CD276 antibodies (B7H3)

Methods of inhibiting pathological angiogenesis in a subject are disclosed. In particular examples, the method includes administering a therapeutically effective amount of a composition to a subject wherein the composition includes a specific binding agent that preferentially binds to one or more pathological angiogenesis marker proteins including Vscp, CD276, ETSvg4 (Pea3), CD137(4-1BB), MiRP2, Ubiquitin D (Fat10), Doppel (prion-PLP), Apelin, Plgf, Ptprn (IA-2), CD109, Ankylosis, and collagen VIII&#x3b1;1. In additional examples, methods to deliver a therapeutic agent to a brain or liver endothelial cell are also disclosed.

Differential gene expression in physiological and pathological angiogenesis

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Martinsburg, WV, United States of America

Steven Seaman