City of Hope

Steven S Smith

Bruce E Kaplan

A nucleoprotein based nanoprocessor is described. The nanoprocessor includes one or more chimelic fusion proteins linked to a DNA scaffold. Both components of the fusion protein are enzymes.

Construction of nucleoprotein based assemblies comprising addressable components for nanoscale assembly and nanoprocessors

A nucleoprotein based nanoprocessor is described. The nanoprocessor includes one or more chimeric fusion proteins linked to a DNA scaffold. Both components of the fusion protein are enzymes.

A reverse transcriptase assay is described. A modular nanostructure comprising relatively small and relatively long RNA sequences is utilized in the assay.

Reverse transcriptase detection and inhibition

Molecules having an RNA block linked to a shorter DNA block is described. The RNA and DNA blocks are complementary to accommodate formation of fold-back molecules having a 3' hydroxyl on the DNA block and an overhanging RNA strand at the end of a short DNA-RNA hybrid.

Growing community of inventors

Los Angeles, CA, United States of America

Steven S Smith