Warner-lambert Company

Steven S Dills

Andrew R Gallopo

Anil K Talwar

Lori D Kumar

Pauline H Pan

Edward J Carlin

Donald M Lynch

Linda T Principe

Deborah A Noonan

The invention provides an anti-bacterial oral composition such as mouthrinse which includes a bis-biguanido hexane compound such as chlorhexidine and compounds thereof, certain non-ionic surfactants which are poly(oxyethylene)-poly(oxypropylene) block copolymers having an HLB of between 10 and 30 or an ethoxylated hydrogenated caster oil containing from about 10 to 200 moles of added ethylene oxide and sorbitol in high concentrations. The oral composition is found to increase the activity of the bis-biguanido compound from 25% to 150%.

Anti-bacterial oral composition containing bis-biguanido hexanes

Compositions having improved anti-plaque and anti-gingivitis activity comprise a synergistic combination of a) a morpholinoamino alcohol or salt thereof, such as 3-(4- propylheptyl)-4-(2-hydroxyethyl) morpholine, and b) a metal salt, such as the salts of divalent zinc, copper and magnesium.

Anti-plaque compositions comprising a combination of morpholinoamino

Bioadhesives microcapsules capable of sustained release comprise xanthan gum, locust bean gum, a bulking agent and an active agent. The microcapsules are particularly useful for delivering buffering agents to the oral cavity for anticaries purposes.

Sustained release of active agents from bioadhesive microcapsules

The present invention pertains to oral antiseptic compositions comprising a therapeutically effective amount of a synergistic antiseptic composition comprising an antiseptic hexahydro-5-pyrimidinamine compound and thymol in an oral vehicle or in a pharmaceutically acceptable carrier such as a confectionery bulking agent. The synergistic antiseptic compositions may be utilized in a wide variety of aqueous-based oral antiseptic products and confectionery products. This invention also relates to methods by which these oral antiseptic and confectionery products may be prepared.

Antiseptic compositions containing hexahydro-5-pyrimidinamine compounds

A tablet having improved bioadhesion to mucous membranes is disclosed. The tablet comprises effective amounts of a water-soluble biopolymer selected from the group consisting of a xanthan gum, a pectin and mixtures thereof; and a solid polyol having a solubility at room temperature in water greater than about 20 grams of polyol per 100 g of solution. Preferably the biopolymer is xanthan gum and the polyol is a sugar alcohol selected from the group consisting of sorbitol, xylitol, and mixtures thereof.

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Hackettstown, NJ, United States of America

Steven S Dills