Chiron Corporation

Hewlett-packard Development Company, L.p.

Xdx, Inc.

Cardiodx, Inc.

Palo Alto Research Center Inc.

The Brigham and Women's Hospital, Inc.

Fina Research, S.a.

Brigham and Women's Hospital Harvard Medical School

Steven Rosenberg

Kirk E Fry

Patricia A Tekamp-Olson

Robert Woodward

Jay Wohlgemuth

Michael V Doyle

Ngoc Ly

James Prentice

MacDonald Morris

Omer Gila

Henryk Birecki

Napoleon J Leoni

Philip J Barr

Alfred I-Tsung Pan

Pablo D Valenzuela

Guy T Mullenbach

Rae Lyn Burke

Prakash D Reddy

Robert A Hallewell

Michael Elashoff

Jeffrey R Shuster

Harold A Chapman

Kerry L Spear

Philip Beineke

Jeffrey M Blaney

Whittemore G Tingley

Jennifer R Stratton-Thomas

James A Wingrove

Susan E Daniels

Doron Shaked

Richard H Bruce

Carl Staelin

Dino Dina

Jian Fan

Peter George Hartwell

Steven Louis Naberhuis

Paul A Luciw

Guy De Warrenne Bruce Adams

Eric J Martin

Anthony J Brake

Nancy L Haigwood

Jacques D Hanotier

Andrew Malcolm Bray

Richard M Thayer

Russell L Dedrick

Bin Wu

Barbara S Chapman

Kristin M Smith

Doug Kaltenecker

Andrew Bolwell

Robert Valerio

Annie De Baetselier

Michael R Elashoff

Embodiments of the present invention are directed to systems and methods for writing on electronic paper ('e-paper') and display platforms implemented with e-paper. In one aspect, a system for writing information to electronic paper includes a writing module and an erasing unit connected to the writing module. The erasing unit is configured to erase information stored in the electronic paper. The system also includes a writing unit connected to the writing module and is configured to write information to the electronic paper. Information is written to the electronic paper by orienting the writing module so that the electronic paper passes the erasing unit prior to passing the writing unit.

Writing electronic paper

Markers and methods useful for assessing coronary artery disease in a subject are provided, along with kits for measuring their expression. Also provided are predictive models, based on the markers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples.

Method for determining coronary artery disease risk

A system and method is disclosed for removing artifacts from a digitized document. The method discloses receiving a digitized document, having an image format, and including content and an artifact; identifying a content boundary within the digitized document; enhancing the digitized document after identifying the content boundary; and removing the artifact by cropping the digitized document to the content boundary after enhancing the digitized document The system discloses a processor configured to operate a series of functional modules, including: a means for receiving a digitized document, having an image format, and including content and an artifact; a content boundary identification module, for identifying a content boundary within the digitized document; an image enhancement module, for enhancing the digitized document after identifying the content boundary; and a content cropping module, for removing the artifact by cropping the digitized document to the content boundary after enhancing the digitized document.

System and method for removing artifacts from a digitized document

A method of providing content to users, with a tool incorporated in a website, includes searching a content database; selecting content from the database; and printing the selected content in book form. A system for providing content includes a content tool; and a service module. The content tool is incorporated in a website and is in communication with the service module. The content tool and service module allow visitors to the website to search, select and customize content located in a database accessible to the service module. The content tool and service module allow the visitors to order a copy of the content.

Providing content to users

The invention presents methods of using splice variants and reagents thereof for diagnosing and monitoring the status of transplants and immune disorders including diagnosing, monitoring and predicting transplant rejection or non-rejection, steroid responsiveness, and onset or flare of immune disorders.

Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders

Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.

Methods and compositions for diagnosing and monitoring transplant rejection

A method is provided for multiple target screening for drug assays utilizing a nanocalorimeter. The method includes depositing a drop containing a plurality of drug targets and another drop containing a plurality of drug candidates upon a test substrate. The drops are merged and a determination is made as to whether a reaction has occurred between the drops. If such a reaction has occurred, the reacting drug targets and drug candidates are tested individually.

Method for multiple target assay for drug discovery

Electronic writing systems and methods are described. In one aspect, an electronic writing system includes an elongated housing, an inertial sensor, an optical sensor, and a tracking module. The elongated housing has an optical input. The inertial sensor is attached to the housing and is operable to generate data indicative of movement of the housing relative to an inertial reference frame. The optical sensor is attached to the housing and is operable to generate data from light received through the optical input. The tracking module is operable to compute relative displacement data from inertial movement data corresponding to data generated by the inertial sensor. The tracking module also is operable to detect at least one calibrated position from calibration data encoded in optical data generated from light received by the optical sensor.

Electronic writing systems and methods

Optically detectable data encoding layouts for surfaces includes a primary lattice and a secondary lattice formed in interstitial areas between plural points on the primary lattice and one or more markings located on points on the secondary lattice. The primary lattice defines the layout of the secondary lattice. The data is encoded according to the positions of the markings on the secondary lattice. The layout provides absolute or relative page position encoding because, when the markings are imaged and decoded, the decoded data corresponds to the position of the corresponding marking on the surface.

Optical coding of position information on printed surfaces

Novel peptides that are capable of binding to uPAR and inhibiting the binding of an integrin and vitronectin are described. Also provided are nucleic acid sequences encoding the novel peptides. Methods for screening for small molecules, other peptides, or peptoids that mimic the antagonistic function of the peptides of the invention are described. The invention has applications in design of therapeutics for treating disorders characterized by upregulation of uPA and uPAR, and cancer and chronic inflammation, cell migration or uPAR: integrin binding interactions, and diagnostical applications to such disorders.

Peptide ligands of the urokinase receptor

Growing community of inventors

Oakland, CA, United States of America

Steven Rosenberg