Corium International, Inc.

Amway Corporation

Ranir, LLC

Corium Corporation

Steven Richard Klemm

Parminder Singh

Joseph Creagan Trautman

Robert Wade Worsham

Danny Lee Bowers

Guohua Chen

Danir F Bayramov

David R Johnson

Andy Klemm

Gary Wynn Cleary

Esi Ghartey-Tagoe

Michael G Marcoux

Janet Wendorf

Steve Williams

Andrew Richard Klemm

Roy M Taylor, Jr

Adrian Faasse

Michael R Foote

Adrian L Faasse

Glen Edward Groeneweg

Alan Gene Thelen

Danir Bayamov

In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.

Solvent-cast microprotrusion arrays containing active ingredient

An adhesive device used as a wound dressing, ingredient delivery device or IV hold-down in which inadvertent edge release of these devices along the periphery of the polymeric film layer is minimized when the handling layer, which is adhered to the polymeric film layer, is removed after application of the polymeric film layer to the patient.

Wound dressing, ingredient delivery device and IV hold-down, and method relating to same

Adhesive devices used as wound dressings, ingredient delivery devices and IV hold-downs include a handling layer comprised of a layer of conductive material and at least one layer of non-conductive material, adhered to the non-adhesive coated side of an adhesive coated polymeric film layer, by an electrostatic charge, rather than by an adhesive.

Wound dressing, ingredient delivery device and IV hold-down incorporating a statically retained handle member

A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another embodiment of the invention, a method of preventing a disease is provided, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer.

Method of vaccine delivery via microneedle arrays

An oral care agent delivery device is provided which comprises a permanently deformable backing layer, an oral care layer, and a non-woven binding material with a first part that is substantially invested in the oral care layer and a second part that is substantially invested in the backing layer. The device is sized to fit over a plurality of teeth in an upper or lower dental arch of a subject. The oral care layer comprises at least one oral care agent and at least one hydrophilic polymer. When hydrated, the oral care layer has an adhesiveness relative to the surface of a user's teeth that is sufficient to retain the device on the user's teeth when placed thereon. The device can also have an oral care agent which is activated on hydration of the oral care layer, or an oral care layer which releases the oral care agent over time.

Device and method for delivering an oral care agent

Vaccine delivery via microneedle arrays

A microneedle applicator is provided which has two roughly concentric portions which may be, for example, a solid disk and an annulus surrounding it. On the skin-facing side of the inner portion of the applicator a microneedle array is located. The outer portion of the applicator is placed against the skin, contacting it at a zone. The microneedle array is then pressed towards the skin.

Applicators for microneedles

A dermal, transdermal, mucosal or transmucosal delivery device includes a backing layer overlying an ingredient containing reservoir, and having a microprotrusion array attached thereto, a cover for the reservoir having at least one opening therethrough, an adhesive layer and a liner layer. Upon removal of the liner layer, the device may be placed over the desired area of the skin or mucosa and adhesively applied thereto allowing the ingredients to flow from the reservoir through the at least one opening to the skin or mucosa.

Transdermal delivery device

Wound dressing, ingredient delivery device and IV hold-down incorporating a statically retained handle

A drain cleaning composition includes at least about 40% by weight of a free-flowing coated alkali metal hydroxide and about 5% to 20% by weight of mixture of a hypochlorite generator and a peroxide generator. The hypochlorite and peroxide generators react to release oxygen gas and hypochlorite ions, the hypochlorite generator being in stoichiometric excess over the peroxide generator to produce free hypochlorite ions for dissolving hair and other protein based clogs. The coating on the drain cleaning composition prevents the hydroxide from reacting with the other components of the mixture before the mixture is added to water.

Drain cleaner

A dispensing pouch containing premeasured laundry compositions comprises a flexible, porous pouch having a plurality of valves or supplementary openings along its edges. The dispensing pouch permits rapid dispersion of a highly soluble laundry detergent through the pouch valves, which open as the pouch is compressed during laundry agitation in a machine washer. Washer-resistant fabric softener/antistatic chips larger than the pouch valve openings remain inside the pouch through wet cycles, to be dispensed as they melt and wick through the porous pouch fabric in a machine dryer.

Dispensing pouch containing premeasured laundering compositions

Growing community of inventors

Grand Rapids, MI, United States of America

Steven Richard Klemm