Bionomics Inc.

The Florey Institute of Neuroscience and Mental Health

University of California

Johns Hopkins University

The University of Queensland

Praxis Precision Medicines, Inc.

Rogcon, Inc.

Samuel Frank Berkovic

Ingrid Eileen Scheffer

Steven Petrou

Eric G Marcusson

David J Julius

Glenn King

Frank Bosmans

Chuchu Zhang

Jeremiah Osteen

The present invention provides methods for determining the phenotype (e.g., gain-of-function or loss-of-function) of a mutation in an ion channel or receptor by using a dynamic voltage clamp. The invention also features methods of determining whether a mutation is a gain-of-function or loss-of-function mutation and treating a disease or disorder associated with the particular gain-of-function or loss-of-function mutation.

Dynamic clamps and methods of use thereof

Provided herein are methods, compounds, and compositions for reducing expression of sodium voltage-gated channel alpha subunit 2 (SCN2A) in a subject. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate a sodium voltage gated channel alpha subunit 1 (SCN1A) related disease or disorder (e.g., Dravet syndrome) in a subject in need.

Antisense oligonucleotides targeting SCN2A for the treatment of SCN1A encephalopathies

Described herein are compositions and methods that are used to increase the expression of SCN2A, which may be used to treat neurological or psychiatric disorders. Antisense oligonucleotides that target upstream open reading frames (uORFs) may be administered to prevent translation initiation from a uORF to increase expression from a primary ORF (pORF), thus increasing the levels of SCN2A protein.

Compositions and methods for increasing expression of SCN2A

This invention relates to peptides and their use for modulating sodium channels. More particularly, the present invention relates to peptides and their use in methods of enhancing Na1.1 activity and for treating or preventing conditions associated with Na1.1 activity.

Proteinaceous molecules and methods of use

A method for the diagnosis of SMEI in a patient comprising:

Diagnostic method for epilepsy

Methods for the diagnosis and treatment of epilepsy

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Eltham, Australia

Steven Petrou