Medical Research Council

Cambridge Antibody Technology Limited

Steven Paul Ruddock

Gregory Paul Winter

Tristan J Vaughan

Kevin Stuart Johnson

Alison Jane Wilton

Philip Ronald Tempest

Ronald Henry Jackson

Andrew James Williams

Julia Elizabeth Thompson

Louise Bacon

Raymond Paul Field

Jonathan Alexander Green

Specific binding members comprising human antibody antigen binding domains specific for human transforming growth factor beta (TGF&#x3b2;) bind specifically isoforms TGF&#x3b2;2 and TGF&#x3b2;1 or both, preferentially compared with TGF&#x3b2;3. Specific binding members may be isolated and utilized in the treatment of disease, particularly fibrotic disease and also immune/inflammatory diseases. Therapeutic utility is demonstrated using in vitro and in vivo models. Full sequence and binding information is provided, including epitope sequence information for particularly advantageous specific binding member which binds the active form of TGF&#x3b2;2, neutralizing its activity, but does not bind the latent member.

Human antibodies specific for TGF&#x3b2;2

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Cambridge, United Kingdom

Steven Paul Ruddock