Audubon Technologies, LLC

Lyzer Diagnostics, Inc.

Carehealth America Corporation

Eveia Medical, Inc.

Steven Patrick Tyrrell

Dean Michael Kingston

Barry Vant-Hull

Corey B Kashiwa

Edward J Hepworth

Timothy Robert Geiger

Christopher Paul Mattison

A system and method for maintaining a patent paranasal sinus ostium includes delivering a tubular element in an insertion state to the sinus ostium. The tubular element includes a proximal end, a distal end, and a center region between the proximal end and the distal end. The method includes expanding the tubular element from the insertion state to a deployment state when the tubular element is located in the sinus ostium. In the deployment state, the center region confronts the sinus ostium with an outward radial force. Other embodiments are disclosed.

Device for maintaining patent paranasal sinus ostia

A lateral flow assay test device providing a structure for the lateral flow assay reactions provides for a continuous flow path of bibulous material provided in separate but contiguous regions of the device in which the bibulous layers are in fluid contact with each other thereby providing flow control of the timing and speed of the assay reaction. Increased flow control results in increasing reliability of use, increasing sophistication of reactions and increases the range of molecules or diagnosis that can be identified. Such flow control can extend processing times and allow users or test givers to manually delay test processing providing enhanced test results.

Lateral flow devices and methods of manufacture and use

There is disclosed a method for maintaining a patent paranasal sinus ostium. In an embodiment, the method includes delivering a tubular element in an insertion state to the sinus ostium. The tubular element includes a proximal end, a distal end, and a center region between the proximal end and distal end. The method includes expanding the tubular element from the insertion state to a deployment state when located in the sinus ostium. In the deployment state, the center region confronts the sinus ostium with an outward radial force.

Provided are methods and devices for separating particulate analytes or aggregates of analytes from a fluid, after the separation medium of the device is saturated with the fluid. The endpoint indicating completion of the separation is determined by saturation; therefore, no precise metering of the fluid sample is necessary. The separated analyte of interest can be detected, quantitated or its migration measured in the separation medium. The measured property of the analyte can then be correlated with a parameter of interest. In some embodiments, the device can be marked to directly read the value of the parameter of interest. In one embodiment, the fluid is blood and the device includes a volumetric capillary reservoir for collecting the blood, a separation paper or indicator strip, and graduations for correlating the migration of red blood cells with hematocrit or hemoglobin concentration. The interface of red blood cells and plasma creates a readable marking that corresponds to percent hematocrit and can be read from the graduations.

Apparatus and methods for separating and analyzing components in fluids

The present invention concerns methods, compositions and apparatus for detection and/or determination of concentration of target molecules. In preferred embodiments the methods comprise allowing target molecules to form a complex with a first binding agent conjugated to a detection molecule and a second binding agent conjugated to a capture molecule, allowing the complex to further bind to an essentially uncharged polymer capable of binding to the capture agent, and performing a vertical gradient electrophoresis to separate the complex from unbound target, first and second binding agents and polymer. The intact complex is concentrated by electrophoresis at a stacking layer and the detection molecule is detected and/or quantified. Because the complex contains a very high mass to charge ratio, it becomes essentially immobile at the stacking layer, while unbound components migrate through the stacking layer and are separated from the complex. This provides a very rapid and sensitive assay that can detect very low concentrations of target molecules in short time.

Rapid homogeneous immunoassay using electrophoresis

Methods and devices for analyzing fluid variables such as viscosity, surface tension, analyte concentration, and the presence of particulates or aggregates are provided. The devices analyze fluid variables by measuring cessation of fluid flow through the medium or a change in flow rate due to an inherent property of the fluid variable, or due to a modification of the fluid variable as the fluid migrates through the medium. The lateral flow devices measure relative rates of capillary flow down converging arms of a common element of porous media in which at least one of the arms has been modified by the addition of flow-modifying agents which affect the flow rate in response to the concentration of the analyte. The fluid fronts will converge at a position determined by their relative flow rates, which is thus indicative of a fluid variable, such as analyte concentration, in the sample fluid.

Apparatus and methods for analyzing fluid variables

Embodiments herein concern systems, methods, compositions and apparatus for detection and/or determination of the presence and/or concentration of target molecules in a sample. In certain embodiments, target molecules can be separated and analyzed using non-gel electrophoresis technologies.

Apparatus, compositions and methods for rapid competitive homogeneous assay

A device for maintaining a patent paranasal sinus ostium includes a tubular element having a proximal end, a distal end, and a center region between the proximal end and distal end. The tubular element has an insertion state and a deployment state. The tubular element is locatable in the sinus ostium when in the insertion state and expandable from the insertion state to the deployment state when located in the sinus ostium. In the deployment state, the center region confronts the sinus ostium with an outward radial force.

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Erie, CO, United States of America

Steven Patrick Tyrrell