Regeneron Pharmaceuticals, Inc.

Sanofi Biotechnology

Other

Steven P Weinstein

Neil John Graham

Allen Radin

Jennifer D Hamilton

Namita A Gandhi

Marius Ardeleanu

Sudeep Kundu

Ross E Rocklin

Jeffrey Ming

Margaret Karow

Neil E Stahl

Scott Mellis

Gianluca Pirozzi

Joanne Papadopoulos

Stephanie C Kirkesseli

Stephane C Kirkesseli

Denise Calaprice

Franck Skobieranda

Yongtao Li

Neil Graham

Marius Ardelenau

The present invention provides methods for treating or preventing asthma and associated conditions in a patient. The methods of the present invention comprise administering to a subject in need thereof a therapeutic composition comprising an interleukin-4 receptor (IL-4R) antagonist, such as an anti-IL-4R antibody.

Methods for treating or preventing asthma by administering an IL-4R antagonist

The invention provides methods for treating or preventing asthma and associated conditions in a patient. The methods featured in the invention comprise administering to a subject in need thereof a therapeutic composition comprising an interleukin-4 receptor (IL-4R) antagonist, such as an anti-IL-4R antibody.

Methods of treating, inhibiting, or ameliorating arthritis, including rheumatoid arthritis, osteoarthritis, psoriatic arthritis, ankylosing spondylitis, or juvenile rheumatoid arthritis, in a human subject in need thereof, comprising administering to a subject in need a therapeutic amount of an interleukin 1 (IL-1) antagonist, wherein arthritis inhibited, or ameliorated. The IL-1 antagonist is an IL-1-specific fusion protein comprising an IL-1 binding portion of the extracellular domain of human II-1RAcP, an IL-1 binding portion of the extracellular domain of human IL-1RI, and a multimerizing component antagonist, preferably comprising a sequence selected from the group consisting of SEQ ID NO:4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, or a substantially identical sequence.

Use of an IL-1 antagonist for treating arthritis

A method and apparatus for communicating specific idiosyncrasies in tooth appearance to be replicated in the fabrication of tooth restorations, as well as a method for creating reference images of a tooth are disclosed. The apparatus contains images of a tooth, wherein categories of specific features are displayed in the images, and codes are assigned to the images according to variations within the categories. The method of communication utilizes the apparatus by allowing a first user to compare an actual tooth to the images, record the codes for images with features that most closely resemble the actual tooth, and transmit the codes to a second user who may reference the same selected images using the recorded codes. The reference images of a particular type of tooth are created by separating and enhancing specific features in photographs of an actual tooth.

Method and apparatus for communicating tooth characteristics and tooth restoration produced thereby

Growing community of inventors

Hartsdale, NY, United States of America

Steven P Weinstein