Cubist Pharmaceuticals, Incorporated

Xenova Limited

Steven Michael Martin

Michael Moore

Roya Mansour Sadeghi Guilani

Stephen Keith Wrigley

Sangeeta Bahl

David Andrew Kau

Martin Alistair Hayes

Neil Robinson

Thomas Haydn Mander

Andrew Jonathan Whiting

Jenny Seugkin Tang

Werner Albert Katzer

David James Hardick

Cytokine production inhibitors

A compound of formula (I), wherein &agr;X is &boxH;O, &boxH;N&mdash;OR , &bgr;NHR or &bgr;OH wherein R is H or C -C alkyl, bond a is oriented &ggr; or &dgr; and R is H, C -C alkyl which is unsubstituted or substituted by C -C aryl, or C -C cycloalkyl; &egr; is a bond when &zgr; and &eegr; are not bonds or, when X is &boxH;O, &zgr; and &eegr; are both bonds and &egr; is not a bond; R and R , which are the same or different, are H or a halogen; R and R , which are the same or different, are H, C -C alkyl, C -C cycloalkyl, a heterocyclic group or an aromatic group; bond e is oriented &ggr; or &dgr;; and R is C -C alkyl; or formula (Ib), or formula (II), or formula (III), has activity as a cytokine production inhibitor and an inhibitor and an inhibitor of tyrosine kinase. A process for producing some of the compounds from a fungal strain, processes for producing synthetic analogues from these compounds and the use of the compounds in treating immunoinflammatory and cancerous conditions are also described.

Cytokine production and tyrosine kinase inhibitors

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Slough, United Kingdom

Steven Michael Martin