Genentech, Inc.

Xenon Pharmaceuticals Inc.

Steven McKerrall

Kwong Wah Lai

Daniel P Sutherlin

Christoph Martin Dehnhardt

Brian Salvatore Safina

Sultan Chowdhury

Thilo Focken

Michael Edward Grimwood

Birong Zhang

Ivan William Hemeon

Philippe Bergeron

Ramsay Beveridge

Wenfeng Liu

Aleksandr Kolesnikov

Claudio F Sturino

Zhiguo Liu

Jean-Philippe Leclerc

Alexandre Lemire

Liang Zhao

Tao Wang

Michael Scott Wilson

Kristen Nicole Burford

Abid Hasan

Shannon Marie Decker

Tao Sheng

Chien-an Chen

Dan Sutherlin

Teresa Phuongtram Nguyen

The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the variables Y-Y, X, Z, Z, Z, R-R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. The compounds have sodium channel blocking activity that are useful for treating sodium channel-mediated diseases, in particular for treating pain.

Pyridine-sulfonamide derivatives as sodium channel inhibitors

The invention provides a compound of formula (I):

Therapeutic compounds and methods of use thereof

The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R, R, subscript n, ring A, X, L, subscript m, X, ring B, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Substituted benzamides and methods of use thereof

The invention provides benzene sulfonamides and pharmaceutically acceptable salt thereof that are useful as sodium channel blockers for the treatment of, for example, pain. The following compound is illustrative: 

The invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein, A, B, ring C, R, R, R, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

The invention provides compounds having the general formula (I): and pharmaceutically acceptable salts thereof, wherein the variables R, R, n, ring A, X, L, m, R, R, R, R, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

Substituted benzamides useful as sodium channel blockers

The invention provides 4-piperidin-chroman-7-sulfonamide derivatives and salts thereof that are sodium channel modulators, as well as compositions containing such a compound or salt and therapeutic methods for using such a compound, salt, or composition.

4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors

The invention provides a compound of formula: or a salt thereof, wherein the variables R, n, ring A, ring B, R, R, R, R, R, R, R, R, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

The invention provides compounds having the general formula I: (i) and pharmaceutically acceptable salts thereof, wherein the variables R, R, subscript n, ring A, X, L, subscript m, X, ring B, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

The invention provides a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein the variables X, Y&#x2014;Y, R, R, R, R, and Het have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

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South San Francisco, CA, United States of America

Steven McKerrall