Smithkline Beecham Corporation

Beecham Group Plc

Steven Mark Bromidge

Barry S Orlek

Stephen Frederick Moss

Steven Dabbs

Francis D King

Paul Adrian Wyman

John Kitteringham

Gary Thomas Borrett

Erol A Faruk

Mark Jason Hughes

Martyn Voyle

Michael S Hadley

Ian Thomson Forbes

Harry J Wadsworth

Sarah Margaret Jenkins

Richard E Faulkner, Deceased

John Keogh

The invention relates to novel tetrahydroquinoline compounds having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of various CNS disorders.

Isoquinoline derivatives useful in the treatment of CNS disorders

Sulphonamide derivatives, process for their preparation, and their use as medicaments

Compounds

Indoline derivatives useful as 5-HT-2C receptor antagonists

The invention relates to novel compounds having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS disorders.

Indoline derivatives useful as 5HT,receptor antagonists and methods of using them to treat various CNS disorders are provided.

Indole derivatives as 5-HT receptor antagonist

A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## in which one of X and Y represents hydrogen and the other represents Z, where Z is a group ##STR2## in which Q represents a 3-membered divalent residue completing a 5-membered aromatic ring and comprises zero, one or two nitrogen atoms, Q being optionally C-substituted by a group R.sub.1 selected from halogen, CN, OR.sub.2, SR.sub.2, N(R.sub.2).sub.2, NHCOR.sub.2, NHCOOCH.sub.3, NHCOOC.sub.2 H.sub.5, NHOR.sub.2, N.sub.3, NHNH.sub.2, NO.sub.2, COR.sub.2, COR.sub.3, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, cyclopropyl or C.sub.1-2 alkyl optionally substituted with OR.sub.2, N(R.sub.2).sub.2, SR.sub.2, CO.sub.2 R.sub.2, CON(R.sub.2).sub.2 or one, two or three halogen atoms, in which each R.sub.2 is independently hydrogen or C.sub.1-2 alkyl and R.sub.3 is OR.sub.2, NH.sub.2 or NHR.sub.2 ; r represents an integer of 2 or 3, s represents an integer of 1 or 2 and t represents 0 or 1; R.sub.a and R.sub.b each represent hydrogen or, when X is hydrogen, optionally together represent a bond; with the proviso that when Y is hydrogen s is 1.

N-linked azabicyclic heterocycles useful for treating dementia

A process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sub.1 represents ##STR2## in which r represents an integer of 2 to 4, s represents 1 or 2 and t represents 0 or 1;

Process for the preparation of azabicycloc derivatives

Derivatives of quinuclidine n-oxide as muscarinic receptor ligands

Azabicyclic compounds and pharmaceutical compositions containing them

1,2,5,6-tetrahydropyridine oxime derivatives

1,2,5,6-tetrahydropyridine oxime compounds

A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sup.1 represents ##STR2## in which each of p and q independently represents an integer of 2 to 4, r represents an integer of 2 to 4, s represents 1 or 2 and t represents 0 or 1;

Azabicylo oxime compounds

Growing community of inventors

Sawbridgeworth, United Kingdom

Steven Mark Bromidge