Eli Lilly and Company

Monsanto Company

Steven Marc Massey

James Allen Monn

David Andrew Coates

Matthew John Valli

Richard Duane Johnston

Ronald Joseph Brinker

Patrick Gianpietro Spinazze

Miles Goodman Siegel

Eric Lee Williams

Douglas Richard Stack

Brett H Bussler

Timothy Barrett Durham

James Lee Toth

Jason Kenneth Myers

Kevin Charles Fortner

Bruce Anthony Dressman

Russell Dean Stucky

Qing Shi

David R Helton

Steven Scott Henry

Francisco Javier Agejas-Chicharro

Mohammad Sadegh Zia-Ebrahimi

Jose Antonio Martinez Perez

Antonio Navarro

Sonia Maria Gutierrez Sanfeliciano

Carmen Dominguez Fernandez

Brett Hayden Bussler

The present invention provides a compound of Formula I. or a pharmaceutically acceptable salt thereof, and the use of compounds of Formula I for treating metabolic conditions, such as type 2 diabetes mellitus, heart failure, diabetic kidney disease, and non-alcoholic steatohepatitis.

Disubstituted pyrazole compounds

The present invention provides a compound of Formula I or a pharmaceutically acceptable salt thereof, and the use of compounds of Formula I for treating metabolic conditions, such as type 2 diabetes mellitus, heart failure, diabetic kidney disease, and non-alcoholic steatohepatitis.

The present invention provides a compound of Formula II: or a pharmaceutically acceptable salt thereof.

CGRP receptor antagonists

The present invention is directed toward pyridyl derivatives of formula (I) as antagonists of the mGlu5 receptor. As such the compounds may be useful for treatment or prevention of disorders remedied by antagonism of the mGlu5 receptor, wherein Ar is phenyl or napthyl each of which may be substituted by one or more C-Calkyl, C-Calkoxy, C-Cacyl, halo, amino, nitro, cyano, hydroxy, C-Cacylamino, C-Calkylsulfonylamino, mono-, di- or trifluorinated C-Calkyl, substituents which may be the same or different and may bear a CONH, CONHCH, CON(CH), COH, COCH, OCF, CHNHCOCH, CHNH, CHN(CH), CHCN, CHOH, CHNHSOCH, CHN(CH)(CH)CN, CHN(CH)CH(CH), CHNHCH(CH), CHNH(CH)CH, CHNHCOR, CHNHCHCH, CHNHCHNHCOC(CH), or N(S(O)CH)substituent; Ris hydrogen, halo, R, CN, C(NOH)R, C(NO&#x2014;R)R, (CH)COR, (CH)OR, COR, CF, SR, S(O)R, S(O)R, COCHCOR, NHSOR, NHCOR, C(NOR)NH, CHOCOR, (CH)NH, CON(CH)(CH)NHCOR, COR, CONH, CSNH, C(NH)NHOR, (CH)N(CH), or CONHNHCOR; Ris 1,2-ethenediyl or 1,2-ethynediyl; Ris hydrogen or C-Calkyl; Ris C-Calkyl; and n is 0, 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof, or an N-oxide thereof. 

Pyridyl derivatives and their use as mGlu5 antagonists

Hydantoin derivatives

Compounds of the formula ##STR1## in which R.sup.1 and R.sup.2 are as defined in the specification, and non-toxic metabolically labile ester and amides thereof are useful as modulators of metabotropic glutamate receptor function.

Excitatory amino acid receptor modulators

Compounds of the formula ##STR1## in which X represents a bond, S, O or NR.sup.a ; and R is as defined in the specification are useful as modulators of metabotropic glutamate receptor function.

3-substituted Bicyclo�3.1.0!hexane-6-carboxylic acids

Compounds for formula I ##STR1## in which X represents O, NR.sup.a, S, SO or SO.sub.2 and R is as defined in the specification; and non-toxic metabolically labile esters or amides thereof; and pharmaceutically acceptable salts thereof are useful as modulators of metabotropic glutamate receptor function.

Excitatory amino acid derivatives

The disclosure herein relates to a new family of haloalkyl oxazolidinyl derivatives as antidotal compounds to reduce injury to crop plants by a variety of herbicides. The antidotal compounds are characterized particularly by having heterocyclyl or spiroheterocyclyl radicals attached to the 5-position of haloalkyl oxazolidine compounds and are especially useful as in-can antidotes against injury by acetanilide and thiocarbamate herbicides to corn, sorghum, soybeans, wheat, rice and other crops.

Herbicidal compositions safened by 5-heterocyclic-substituted

5-heterocyclic-substituted oxazolidine dihaloacetamides

Growing community of inventors

Indianapolis, IN, United States of America

Steven Marc Massey