The Johns Hopkins University

Cybernet Systems Corporation

Other

Boston Scientific Corporation

Steven M Rowe

Charles J Jacobus

Martin Gilbert Pomper

Glenn J Beach

Douglas Haanpaa

Xing Yang

Sridhar Nimmagadda

Stephanie Slania

Ronnie Charles Mease

Sangeeta Ray

John E Abele

Christopher A Rowland

Michael G Vergano

Il Minn

Mohamad Allaf

Michael Gorin

Imaging and radiotherapeutics agents targeting fibroblast-activation protein-α (FAP-α) and their use in imaging and treating FAP-α related diseases and disorders are disclosed.

Imaging and radiotherapeutics agents targeting fibroblast-activation protein-α (FAP-α)

Imaging and radiotherapeutics agents targeting fibroblast-activation protein-alpha (FAP-alpha)

Autonomous vehicles are capable of executing missions that abide by on-street rules or regulations, while also being able to seamlessly transition to and from 'zones,' including off-street zones, with their our set(s) of rules or regulations. An on-board memory stores roadgraph information. An on-board computer is operative to execute commanded driving missions using the roadgraph information, including missions with one or more zones, each zone being defined by a sub-roadgraph with its own set of zone-specific driving rules and parameters. A mission may be coordinated with one or more payload operations, including zone with “free drive paths” as in a warehouse facility with loading and unloading zones to pick up payloads and place them down, or zone staging or entry points to one or more points of payload acquisition or placement. The vehicle may be a warehousing vehicle such as a forklift.

Autonomous vehicles and methods of zone driving

Autonomous vehicles are capable of executing missions that abide by on-street rules or regulations, while also being able to seamlessly transition to and from 'zones,' including off-street zones, with their our set(s) of rules or regulations. An on-board memory stores roadgraph information. An on-board computer is operative to execute commanded driving missions using the roadgraph information, including missions with one or more zones, each zone being defined by a sub-roadgraph with its own set of zone-specific driving rules and parameters. A mission may be coordinated with one or more payload operations, including zone with 'free drive paths' as in a warehouse facility with loading and unloading zones to pick up payloads and place them down, or zone staging or entry points to one or more points of payload acquisition or placement. The vehicle may be a warehousing vehicle such as a forklift.

Highly potent and selective radionuclide-based imaging and therapy agents targeting carbonic anhydrase IX with minimum non-specific organ uptake are disclosed. Methods of imaging and/or treating carbonic anhydrase IX-expressing cells or tumors also are disclosed.

Nuclear imaging and radiotherapeutics agents targeting carbonic anhydrase IX and uses thereof

Bottle

Combined bottle and cap

A catheter includes a flexible elongated catheter body that defines a needle-receiving, or probe-receiving, lumen, a retractable tissue-penetrable needle, or probe, and an electrode mounted on the distal portion of the catheter body. The needle provides a fluid passage for introducing fluid into tissue to permit the introduction of sclerotic agents for enhancing electrocoagulation of the tissue, heat-responsive drugs for improving the bonding to tissue surfaces, or vaso-constrictor drugs. The probe can also have a passage for fluid. The electrode can provide bipolar electro-coagulation of tissue in combination with an additional electrode mounted on the catheter body, or alternatively, the electrode can be employed in combination with either the needle or probe to establish a bipolar electro-coagulation path through tissue. The needle, or probe, in combination with an external electrode can be used to provide unipolar electro-coagulation, or ablation. In certain instances, the electrode can be used to provide a mapping function inside cardiac chambers.

Electro-coagulation and ablation and other electrotherapeutic treatments

Growing community of inventors

Las Vegas, NV, United States of America

Steven M Rowe