Biothera Inc.

Steven M Leonardo

Nandita Bose

Keith B Gorden

Jeremy Graff

Xiaohong Qiu

Anissa S H Chan

Nadine Ottoson

Takashi Kangas

Kathryn A Fraser

Adria Bykowski Jonas

Ross Fulton

Michael E Danielson

John P Vasilakos

Mary A Antonysamy

William J Grossman

Anissa Sh Chan

This disclosure relates to the combination of soluble &#x3b2;-glucan and immune suppression-relieving agents that affect the tumor microenvironment. Soluble &#x3b2;-glucan promotes an immunostimulatory environment, which allows enhanced effectiveness of anti-angiogenics, checkpoint inhibitors including non-tumor targeting antibodies.

&#x3b2;-glucan methods and compositions that affect the tumor microenvironment

The present invention relates to the combination of soluble &#x3b2;-glucan and anti-cancer agents that affect the tumor microenvironment. Soluble &#x3b2;-glucan promotes an immunostimulatory environment, which allows enhanced effectiveness of anti-cancer agents.

Beta-glucan in combination with anti-cancer agents affecting the tumor microenvironment

Described herein are beta-glucan compounds, compositions, and methods. Generally, the methods exploit the observation that beta-glucan compounds can bind to B cells. Thus, the methods generally include administering a beta-glucan compound to a subject in an amount effective for the beta-glucan compound to bind to a B cell and modulate at least one biological function of the B cell.

Beta-glucan compounds, compositions, and methods

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Eagan, MN, United States of America

Steven M Leonardo