Merck + Co., Inc.

Steven M Hutchins

Wallace T Ashton

William J Greenlee

Linda L Chang

Malcolm MacCoss

Ronald M Kim

Kevin Tyler Chapman

Ralph A Rivero

Mahua Manna

The present invention is directed to the use of a soluble polyvalent support for the preparation of combinatorial libraries of compounds. The resultant combinatorial libraries are useful in screening for biologically active moieties in the drug discovery process or in developing compounds with desired physical and chemical properties.

Combinatorial synthesis on soluble polyvalent supports having a discrete

Carbamoyl and oxycarbonyl derivatives of biphenylmethylamines of structure I are angiotensin-II antagonists with balanced AT.sub.1 and AT.sub.2 activity useful in the treatment of hypertension and related disorders and ocular hypertension. ##STR1## where X is --O-- or --N(R.sup.7)--.

Substituted carbamoyl and oxycarbonyl derivatives of biphenylmethylamines

Substituted pyrazole compounds are angiotensin II antagonists and therefore useful in the treatment of hypertension, and related cardiovascular disorders and ocular hypertension. These compounds have the general formula I: ##STR1##

Substituted pyrazoles, compositions and use

There are disclosed substituted imidazo[1,2-b][1,2,4]triazole derivatives of Formula I which are useful as angiotensin II antagonists. ##STR1##

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Iselin, NJ, United States of America

Steven M Hutchins