The J. David Gladstone Institutes

University of California

The J. David Gladstone Institutes, a Testamentary Trust Established Under the Will of J. David Gladstone

The J. David Gladstone Institutes, a Testimentary Trust Established Under the Will of J. David Gladstone

Steven M Finkbeiner

Michael A Pleiss

Dale Michael Ando

Aaron C Daub

Andrey S Tsvetkov

Robert Greenhouse

Vikram Ramnath Rao

Sarah Rosemary Carter

Eva Suzanne LaDow

Hong Joo Kim

Matthew Campioni

Jeremy Linsley

Kevan Shah

The present disclosure provides automated robotic microscopy systems that facilitate high throughput and high content analysis of biological samples, such as living cells and/or tissues. In certain aspects, the systems are configured to reduce user intervention relative to existing technologies, and allow for precise return to and re-imaging of the same field (e.g., the same cell) that has been previously imaged. This capability enables experiments and testing of hypotheses that deal with causality over time with greater precision and throughput than conventional microscopy methods.

Automated robotic microscopy systems

The present invention relates to substituted benzoxazines and related compounds and derivatives thereof and/or pharmaceutically acceptable salts, compositions, and methods of uses thereof.

Substituted benzoxazine and related compounds

The present invention relates to compounds including but not limited to of any one of formulas Ia, Ib, IIa, IIb, IIIa, IIIb, and IV to VI, VIIa, VIIb, VIIIa, VIIIb and VIIIc as described herein and their tautomers and/or pharmaceutically acceptable salts, compositions, and methods of uses thereof.

The present disclosure provides methods for treating neurological disorders, generally involving modulating protein kinase D1 (PKD1) activity levels in a neuron or glial cell in an individual in need thereof. The present disclosure provides antibodies specific for PKD1. The present disclosure provides a genetically modified non-human mammal deficient in PKD1 activity.

Compositions and methods for treating neurological disorders

The invention comprises a robotic microscope system and methods that allow high through-put analysis biological materials, particularly living cells, and allows precise return to and re-imaging of the same field (e.g., the same cell) that has been imaged earlier. This capability enables experiments and testing hypotheses that deal with causality over time intervals which are not possible with conventional microscopy methods.

Robotic microscopy systems

Antibodies, as well as binding fragments and mimetics thereof, that specifically bind to polyglutamine expansion containing proteins, e.g. mutant huntingtin protein, are provided. The subject binding agents, e.g. antibodies, fragments and mimetics thereof, etc., are characterized in that they bind to the target polyglutamine expansion containing protein in a manner that differs from the 1C2 antibody, e.g. in terms of affinity, avidity, and the like. Also provided are methods of screening compounds for polyglutamine expansion protein binding modulation activity, as well as pharmaceutical compositions of such agents. In addition, methods and devices for screening samples for the presence of polyglutamine expansion containing proteins, e.g. mutant huntingtin protein, are provided. Finally, nucleic acids encoding the subject antibodies and methods for their expression, including in therapeutic treatment protocols, are provided.

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Corte Madera, CA, United States of America

Steven M Finkbeiner