Ym Biosciences Inc.

Universiteit Gent

Pharsight Corporation

Steven Louis Shafer

Diana H Pliura

Orlando Ricardo Hung

Jon Hartlaub

Tom De Smet

Jean-Max Vally

Laura S Diamondstone

Michel M R F Struys

E Gregory Lee

The present invention provides a system and method for determining and maintaining a concentration level of medication in a patient sufficient to achieve and maintain a desired effect on that patient. Generally speaking, in accordance with one embodiment of the invention, a medication delivery controller uses a patient response profile to determine a concentration of medication in the patient that will achieve the desired effect on the patient. The patient response profile is a graphical, tabular or analytical expression of the relationship between the concentration of a medication and the effect of the medication at the specific concentration. Using this information, the medication delivery controller provides instructions to a medication delivery unit such as, for example, an infusion pump or inhalation device, to deliver the medication to the patient at a rate that will achieve the desired concentration level of the medication in the patient.

System and method for adaptive drug delivery

An opioid formulation for pulmonary administration in the treatment or management of pain, a pulmonary drug delivery device containing, method of administering, kit containing, and uses of same. The formulation contains at least one rapid-onset opioid and preferably also contains a sustained-effect opioid to reduce the frequency of administration. The invention employs the side effects of the opioid formulation to permit patients to self-limit drug intake, thereby avoiding toxicity while achieving analgesia. A pharmacokinetic and pharmacodynamic model is employed to determine optimum drug formulations and optimum parameters for administration.

Opioid delivery system

Methods of performing temporal logic queries, and systems for performing temporal logic queries, are disclosed. Data associated with statistical reliability criteria are annotated in a data source. Baseline data stored in the data source is summarized. Temporal data requests made upon the data source are automatically merged with the data associated with the statistical reliability criteria, to produce a statistically valid data query. Data query results are optionally provided to a statistics module for processing of statistical analyses.

Systems and methods for performing temporal logic queries

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Mountain View, CA, United States of America

Steven Louis Shafer