Medtronic, Inc.

Cardionomic, Inc.

University of Minnesota

St Jude Medical, Atrial Fibrillation Division, Inc

Cardionomia Inc.

Steven Lawrence Waldhauser

Phillip C Falkner

H Toby Markowitz

Chad Giese

Mustafa Karamanoglu

Ioana Fleming

Pooja Mehta

David Scanlon

Michael Kryger

Sean Campbell-Massa

Eduardo N Warman

Rogier Receveur

Vincent Larik

Koen J Michels

Olaf Eick

Shangqian Peter Zhang

Jeff Jannicke

James Steeves

Don Hefner

Kendra Yasger

Steven D Goedeke

Ronald A Drake

Andrea Jean Asleson

Scott William Hayden

Lindsey Marie Tobin

James F Kelley

Erik Griswold

Stanten C Spear

James Calvin Allan

Rudolph A Beasley

Mark R Christianson

Timothy G Laske

Don H Tran

Michael William Kimmel

Steven C Christian

Gregory P Shipe

Mark T Stewart

William John Havel

Mark A Christopherson

David A Anderson

Alan David Eskuri

William Berthiaume

Jon D Schell

Linnea R Lentz

Kenneth W Keeney

Catherine E Taylor

Martha Barajas-Torres

Karl Evan Nowak

Brian Houston Craig

Lonnie D Ronning

Naim S Istephanous

Kelly M Wien

Noelle Christine Hurtig

Lane A Phillips

Suruchi Anand

Victoria Interrante

Brent Chelgren

Matthew S Poole

Marie P Smith

Arvind K Srinivas

Javier J Echenique

Todd Alan Kerkow

Randy A Lieberman

Kimberly A Oleson

Deanna K Levenhagen

Charles L Euteneuer

Paul T Rothstein

Mark T Marshall

Eric H Bonde

Kenneth C Gardeski

Dale F Seeley

Gabriela C Molnar

Duane Frion

James R Skarda

Michael Jay Ebert

David J Serdar

Gary R Fiedler

Patrick P Senarith

Bret R Shoberg

John Her

Bruce E Chivers

Mark D Schneider

Clare E Padgett

Martin J Clements

Peter Zhang

Jeff B Geske

Jeffrey B Geske

Eduard T Teisanu

David Christopher Olson

David A Scanlon

Paula Marcia Kaplan

William G Besser

Duane G Frion

Gabriela Cristina Molnar

Michelle Leslie Kennefick

Chad Allen Thorstenson

John Son Her

A method of detecting catheter movement includes positioning a first sensor in a first body cavity, monitoring a first parameter profile of the first body cavity, positioning a second sensor in a second body cavity, monitoring a second parameter profile of the second body cavity, the second parameter profile different than the first parameter profile at a first time, and, when the second parameter profile is the same as the first parameter profile at a second time after the first time, taking a catheter movement action.

Systems for detecting catheter movement

A system for application of neurostimulation includes an outer sheath, an elongate inner member in the outer sheath and movable relative to the outer sheath. The inner lumen has a distal end. An expandable member is coupled to the distal end of the inner member and is in the outer sheath. The expandable member is self-expanding upon from a compressed state in the outer sheath to an expanded state out of the outer sheath. The expandable member includes a distal portion including a plurality of wires woven together and a proximal portion including the plurality of wires extending parallel to a longitudinal axis. The system includes a plurality of electrode assemblies outward of the expandable member and circumferentially spaced around the expandable member. Each electrode assembly is coupled to two of the wires extending parallel to the longitudinal axis. Each electrode assembly includes a plurality of longitudinally-spaced electrodes.

Electrode assemblies for neuromodulation

A device includes a handle, an expandable structure including a plurality of splines extending from a proximal hub to a distal hub, a first electrode on a first spline of the plurality of splines, an outer tube extending from the handle to the proximal hub, and a shaft extending through the outer tube from the handle to the distal hub. The expandable structure has a collapsed state and a self-expanded state. The handle is configured to retract the shaft. Retracting the shaft may expand the expandable structure outward of the self-expanded state.

Electrode assemblies for neurostimulation treatment

Partially woven expandable members

Methods of positioning neurostimulation devices

Embodiments of the present disclosure provide for catheters for use in electrical neuromodulation. The catheter of the present disclosure includes an elongate body having a first end and a second end. The elongate body includes a longitudinal center axis that extends between the first end and the second end. The elongate body further includes three or more surfaces that define a convex polygonal cross-sectional shape taken perpendicularly to the longitudinal center axis. The catheter further includes one or more electrodes on one surface of the three or more surfaces of the elongate body, where conductive elements extend through the elongate body. The conductive elements can conduct electrical current to combinations of the one or more electrodes.

Catheter and electrode systems for electrical neuromodulation

The present disclosure provides for a method for treating a patient in which a catheter having an electrode array is moved through the pulmonary trunk of the patient towards a branch point that helps to define the beginning of a left pulmonary artery and a right pulmonary artery of the heart. The electrode array is positioned in the right pulmonary artery where the electrodes contact a posterior surface, a superior surface and/or an inferior surface of the right pulmonary artery. The one or more electrodes can be positioned to contact the posterior surface, the superior surface and/or the inferior surface of the right pulmonary artery at a position superior to the branch point. The electrode array can also be positioned in the right pulmonary artery no more than three times the diameter of the pulmonary trunk to the right of the branch point.

Methods for electrical neuromodulation of the heart

A catheter having an elongate body, at least two elongate stimulation members extending from the elongate body, at least one electrode on each of the elongate stimulation members, where the electrodes form an electrode array that receives and conducts electrical current. The elongate stimulation members curve only in the first volume defined at least in part by a first plane, and a second volume defined at least in part by the first plane and being opposite the first volume can contain no electrodes. The catheter can further include a position gauge having a marking that indicates a length between a second end of the elongate body and a bumper end of the position gauge. The catheter can also include a pulmonary artery catheter having a lumen, where the catheter extends through the lumen of the pulmonary artery catheter.

Catheter and catheter system for electrical neuromodulation

A method of facilitating therapeutic neuromodulation of a heart of a patient includes positioning an electrode in a pulmonary artery, positioning a sensor in vasculature, delivering via a stimulation system first and second electrical signals of a series of electrical signals to the electrode. The second electrical signal differs from the first electrical signal by a magnitude of a first parameter of a plurality of parameters. The method includes determining, via the sensor, sensor data indicative of one or more heart activity properties in response to the delivery of the series of electrical signals, and delivering a therapeutic neuromodulation signal to the pulmonary artery using selected electrical parameters. The selected electrical parameters include a selected magnitude of the first parameter. The selected magnitude of the first parameter is based at least partially on the sensor data. The therapeutic neuromodulation signal increases heart contractility.

Cardiac modulation facilitation methods and systems

In one example, this disclosure is directed to a kit for intravascular implantation of an implantable medical device, the kit comprising an outer sheath, the outer sheath sized to traverse a vasculature of the patient, and an elongated inner sheath with a tapered distal end. The inner sheath is slidable within the inner lumen of the outer sheath and is selectably removable from the inner lumen of the outer sheath by sliding the inner sheath out of the proximal opening of the outer sheath. The kit includes an elongated deployment receptacle including a deployment bay slidable within the inner lumen of the outer sheath when the inner sheath is not within the inner lumen of the outer sheath. The deployment bay carries an implantable medical device through the inner lumen of the outer sheath and facilitates deployment of the implantable medical device from the distal end of the outer sheath.

Pass-through implantable medical device delivery catheter with removeable distal tip

Methods of facilitating positioning of electrodes

In one example, this disclosure is directed to a method for intravascular implantation of an implantable medical device comprising positioning a distal end of an elongated outer sheath forming an inner lumen adjacent a target site within a vasculature of a patient, and partially deploying an implantable medical device from the distal opening, wherein the implantable medical device includes an expandable fixation element. A portion of the expandable fixation element assumes an expanded position when the implantable medical device is partially deployed from the distal opening. The method including advancing the distal end of the outer sheath within the vasculature with the implantable medical device partially deployed from the distal opening, and monitoring at least one of the vasculature and the portion of the expandable fixation element for deflection to determine when the size of the portion of the expandable fixation element corresponds to the size of the vasculature.

Implantable medical device deployment within a vessel

A medical apparatus includes an electrically conductive lead for a medical device, the lead having an internal bore terminating at a distal lead opening, and a lead delivery device for delivering the distal end of the lead to a blood vessel during implantation of the lead. The lead delivery device includes a removably anchorable guidewire, and a fixator attached to a distal portion of the guidewire for anchoring the guidewire. The fixator is movable between a compact configuration and an expanded configuration. The fixator is capable of passing through the distal lead opening of the lead in the compact configuration. The fixator is capable of exerting a holding force in the range of about 0.89 to 4.45 N in the lumen of the blood vessel in the expanded configuration.

Lead delivery device and method

In one example, this disclosure is directed to a kit for intravascular implantation of an implantable medical device within a patient, the kit comprising an elongated outer sheath forming a first inner lumen with a distal opening, the outer sheath sized to traverse a vasculature of the patient, and an elongated inner sheath forming a second inner lumen. An outer diameter of the inner sheath is smaller than the diameter of the first inner lumen such that the inner sheath fits within the first inner lumen, wherein the inner sheath is slidable within the first inner lumen. The second inner lumen at a distal end of the inner sheath is configured to carry an implantable medical device. The inner sheath forms a slit at a distal end of the inner sheath to facilitate deployment of the implantable medical device out of the distal opening of the outer sheath.

Implantable medical device delivery with inner and outer sheaths

A medical apparatus includes a guidewire and a fixator catheter. The fixator catheter comprises a tubular body with a distal portion and a proximal portion, and further includes a distal opening, a fixator secured to the distal portion, and a body opening arranged between the fixator and the proximal portion. The guidewire passes through the body opening and the distal opening of the fixator catheter. The fixator is movable between a compact configuration and an expanded configuration and, in the expanded condition, is capable of anchoring the guidewire and fixator catheter in a lumen of a blood vessel.

Growing community of inventors

White Bear Township, MN, United States of America

Steven Lawrence Waldhauser