Children's Research Institute, Children's National Medical Center

Other

University System of Maryland

Steven L Zeichner

Guerau Fernandez

Anthony Sandler

Katherine Davenport

Hope Jackson

Claire Fraser

Emmanuel Mongodin

A method for determining a likelihood of appendicitis in a subject is disclosed. The method comprises the steps of (a) determining the relative abundance of microorganisms corresponding to one or more operational taxonomic units (OTUs) in a test biological sample obtained from the subject; (b) comparing the relative abundance of the microorganisms in each of the one or more OTUs to a corresponding reference value assigned to each of the one or more OTUs, and (c) determining a likelihood of appendicitis in the subject based on the result in step (b), wherein a significant increase in relative abundance of the microorganisms in the one or more OTUs indicates a high risk of appendicitis in the subject. Also disclosed is a kit for determining a likelihood of appendicitis in a subject.

Compositions and methods for determining the likelihood of appendicitis

A method for screening biomolecules molecules is disclosed. One embodiment of the method includes inoculating an expression library or a portion of the expression library into an animal, monitoring the relative abundance of individual members of the expression library; and analyzing molecules expressed by members that show significantly reduced relative abundance after inoculation into the animal. Also disclosed is an expression vector and an expression library employing the vector.

Method for screening biomolecules

A method for treating latent HIV infection is disclosed. The method includes administering to a subject in need of such treatment an effective amount of an anti-I&#x3ba;B&#x3b1; agent, an anti-I&#x3ba;B&#x3b5; agent or both; and administering to the subject an effective amount of an antiviral agent. A pharmaceutical composition for treating latent HIV infection is also disclosed.

Method and compositions for treating HIV infection

Methods and compositions for treating HIV infection

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Bethesda, MD, United States of America

Steven L Zeichner