Other

Cyberonics, Inc.

Biomedical Device Consultants, Inc.

Kevtek Medical Products, Inc.

Steven L Weinberg

Warren Kirschbaum

Anthony J Bradshaw

Albert E Raizner

Michael L Brodman

A source wire having a radioactive source at its distal tip is used to treat tissue at a target site within a patient's body by localized in vivo radiation. The source wire is advanced to the target site along the intravascular system of the patient's body from a point external to the body. The source wire is a solid lead of substantially uniform thickness along its entire length, composed of nickel-titanium alloy (nitinol). Alternatively, the wire may be a cable composed of multiple strands of the alloy of substantially uniform thickness throughout the entire length of each strand. The alloy has desired characteristics including flexibility, springiness, slipperiness, mechanical strength and shape memory retention, and the source wire is imparted with certain stressed and unstressed states that depend on flexation of the wire and a prescribed transition temperature. The wire has a diameter suitable for passage into the coronary arteries, and the distal end of the wire is tapered for ease of entry into narrowed portions. The tissue to be treated lies along a portion of the interior surface of a coronary artery which has been subjected to an angioplasty procedure to reduce blockage of the lumen and thereby improve blood flow. However, the angioplasty procedure may itself initiate restenosis. The targeted tissue is irradiated only briefly, with the radioactive source of the source wire centered as much as practicable in the lumen of the coronary artery, as by use a channeled centering balloon. This allows substantially uniform radiotherapy of the targeted tissue.

Method of treating a body vessel or duct with radiation from within the lumen

The present invention relates to artificial blood and blood substitutes and supplements made by a process for cross-linking a proteinaceous material including an oxygen transport/binding protein such as hemoglobin, methhemoglobin, myoglobin and hemocyanin. The process comprises: i) soaking the proteinaceous material including the oxygen transport/binding protein to be cross-linked in an aqueous solution of high osmolality; ii) incubating the material in an aqueous buffer including an amount of a photooxidative catalyst sufficient to catalyze photooxidation of the material; and iii) irradiating the material and the catalyst of step (i) with light that includes a range of wavelengths selectively absorbed by the catalyst. Irradiation is effected under conditions such that cross-linking of the material occurs.

Cross-linked oxygen binding proteins

A method of making a nerve electrode is performed by forming an electrically insulative resilient array having an elongate backbone member with a plurality of spaced-apart substantially parallel bands, each spanning 360.degree., linked together by the backbone member and skewed from a direction normal to the backbone member; providing non-aligned single openings in the bands to render each of them incomplete with the remaining segments of each band linked by the backbone member and adapted to be spread apart to mount the array over the nerve and, when released, to resiliently close about the nerve; and securing an electrically conductive filament within at least one of the bands.

Method of making a nerve electrode array

A composite of an insulative layer and a fire retardant fabric which is used to make protective articles for laser surgery and which possesses favorable burning, flashing, and resistance to burn through properties. The insulative layer is preferably a hydrogel or other hydrophilic material such as a polyurethane, collagen, polyacrylonitrile, polyvinyl alcohol, or polyvinyl acetal. The fire retardant fabric is preferably a fabric woven or knitted from polyamide or polyimide fibers having a thickness sufficient to provide the desired degree of protection.

Protective articles for use in laser surgery

A nerve electrode array includes one or more spiral electrically conductive filament bands each secured within a different electrically insulative loop among a plurality of loops configured in a helical array. Each loop is severed lengthwise of the array to allow it to be spread open independently of the other loops to partly encircle the nerve during surgical mounting thereon. The array is held together in the helical configuration by a linking member which intersects with and is fastened to each of the spaced-apart loops. Each filament band extends within its loop across the intersection of the loop and linking member. In one embodiment, the cuts through the loops are aligned lengthwise of the helical array and substantially parallel to the linking member, and each cut is approximately diametrically opposite the linking member. In another embodiment, the cuts through the loops are staggered relative to the linking member, lengthwise of the array. With the electrode array mounted on the nerve, the filament bands are positioned to electrically interact with the nerve to detect signals carried by the nerve and/or to electrically stimulate the nerve.

Helical nerve electrode

A composite of an adhesive layer, foil, a fire retardant fabric, and a hydrogel which is used to protect objects during laser surgery and which possesses favorable burning, flashing, and resistance to burn through properties. The hydrogel is preferably a hydrophilic material such as a polyurethane, collagen, polyacrylonitrile, polyvinyl alcohol, or polyvinyl acetal. The fire retardant fabric is preferably a fabric woven or knitted from polyamide or polyimide fibers having a thickness sufficient to provide the desired degree of protection. The composite is applied to the object to be protected, which can be a person or an endotracheal tube or surgical instrument, using the adhesive to adhere the composite thereto.

Composite for use in making protective articles for use in laser surgery

A device for inserting into the vagina of a patient for delivery of a medicament in the vagina. The walls of the tubular member comprising the device are comprised of water-swellable materials having a higher porosity at one end than the other, the relatively low porosity end being positioned distally in the vagina to the relatively high porosity end. The medicament is contained within a reservoir in the tubular member and delivered to the vagina through the pores in the walls of the tubular member at different rates depending upon the porosity. Also provided is a method of delivering a medicament to the vagina of a patient.

Growing community of inventors

League City, TX, United States of America

Steven L Weinberg