Bristol-myers Squibb Compnay

E. R. Squibb Sons, Inc.

Bristol Meyers Squibb Company

Steven L Goldberg

Ramesh N Patel

Robert M Johnston

Venkata B Nanduri

Laszlo J Szarka

Ronald L Hanson

John J Venit

Paul M Cino

Mary Jo Donovan

Paul Alan Jass

Amit Banerjee

Animesh Goswami

Keith Ramig

Wen-sen Li

William John Winter

Jerome L Moniot

Sushil K Srivastava

Shankar Swaminathan

Zhiwei Guo

Gerard Crispino

Neal G Anderson

David A Lust

Kishta Katipally

Thomas P Tully

Linda Chu

Linda Nga Hoong Chu

Yijun Chen

K David Mirfakhrae

Robert M Johnson

This invention relates to isolated or recombinant N-carbobenzyloxy-deprotecting enzyme polypeptides that catalyze the removal of carbobenzyloxy from carbobenzyloxy-protected amino acids and alcohols. Also related are isolated nucleic acids encoding N-carbobenzyloxy-deprotecting enzyme polypeptides thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using the polypeptides in various reactions for industrial or pharmaceutical applications.

N-carbobenzyloxy (N-CBZ)-deprotecting enzyme and uses therefor

This invention relates to isolated or recombinant N-CBZ-deprotecting enzyme polypeptides that catalyze the removal of CBZ from CBZ-protected amino acids and alcohols, and variants, modifications, and fragments thereof. Also related are isolated nucleic acids encoding N-CBZ-deprotecting enzyme polypeptides, and variants, modifications, and fragments thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using polypeptides in various reactions for industrial or pharmaceutical applications.

N-carbobenzyloxy (N-CBZ)-deprotecting enzyme

The invention relates to a process for the enzymatic, stereoselective reduction of ketone compounds to provide chiral alcohols, for example the compound of formula Ib: 

Stereoselective reduction process for the preparation of pyrrolotriazine compounds

This invention relates to isolated or recombinant N-carbobenzyloxy-deprotecting enzyme polypeptides, and variants and fragments thereof, that catalyze the removal of carbobenzyloxy from carbobenzyloxy-protected amino acids and alcohols. Also related are isolated nucleic acids encoding N-carbobenzyloxy-deprotecting enzyme polypeptides, and variants, and fragments thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using the polypeptides in various reactions for industrial or pharmaceutical applications.

This invention relates to a recombinantformate dehydrogenase (FDH) enzyme that catalyzes the oxidation of formate to carbon dioxide and the simultaneous reduction of nicotinamide adenine dinucleotide (NAD+) to its reduced form (NADH). Also related are isolated nucleic acids encodingFDH polypeptides, and fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated, recombinantFDH polypeptides, and fragments and variants thereof, and antibodies that specifically bind toFDH polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolatedFDH nucleic acids, polypeptides, and antibodies, and methods of usingFDH in various reactions for industrial or pharmaceutical applications.

Pichia pastoris formate dehydrogenase and uses therefor

This invention relates to an novel2-ketoreductase useful for the synthesis of chiral alcohols. Also related are isolated nucleic acids encoding2-ketoreductase enzymes, and enzyme fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated2-ketoreductase polypeptides, and fragments and variants thereof, and antibodies that specifically bind to2-ketoreductase polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated2-ketoreductase nucleic acids, polypeptides, and antibodies, and methods of using2-ketoreductase in various reactions for industrial or pharmaceutical applications.

Gluconobacter oxydans 2-ketoreductase enzyme and applications thereof

The present invention is directed to novel stereoselective processes for the preparation of (S)-1-arylethanols by the reduction of the corresponding keto group containing compounds by microorganisms. (S)-1-arylethanols are useful as intermediates in the synthesis of compounds that are inhibitors of &ggr;-secretase useful in the treatment of Alzheimer's disease.

Stereoselective reduction of substituted acetophenone

The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.

Enzymatic oxidative deamination process

Processes for stereoselective enzymatic conversion of certain keto carboxylic acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase, as well as an engineered host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase enzyme and nucleic acid capable of expressing a formate dehydrogenase enzyme.

Stereoselective reductive amination of ketones

Nucleic acid sequences, particularly DNA sequences, coding for all or part of a lipase of Pseudomonas fluorescens, wherein said lipase has the amino acid sequence encoded by the nucleotide sequence of the BamHI/HindIII insert of the plasmid pRJ-Ltac1 from Escherichia coli BL21/pRJ-Ltac1 deposited with the American Type Culture Collection, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of a lipase of Pseudomonas fluorescens, wherein said lipase has the amino acid sequence encoded by the nucleotide sequence of the plasmid pRJ-Ltac1 from Escherichia coli BL21/pRJ-Ltac1 BamHI/HindIII insert of deposited with the American Type Culture Collection, and methods for producing these polypeptides.

Pseudomonas fluorescens lipase

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Basking Ridge, NJ, United States of America

Steven L Goldberg