Becton Dickinson and Company Limited

Steven Keith

John D DeNuzzio

Ronald J Pettis

William J Allen

Todd M Chelak

Lee Griswold

Robert E West

Lawrence A Monahan

Kristin Weidemaier

Phyllis J Palmer

Elaine McVey

Bill Stewart

Frederick Karl

Vincent J Sullivan

Alexander George Lastovich

Robert E Pearson

Matthew S Ferriter

James L Schram

Christian Sandmann

Richard Klug

Joshua Herr

Helen V Hsieh

Adam C Curry

Christopher Rini

Andrea Liebmann-Vinson

Rajendra R Bhat

Natasha Bolick

Alfred Joseph Harvey

W William Stewart

Frances Poyen Tong

John D Denuzzio

J Bruce Pitner

Glenn P Vonk

Douglas Byron Sherman

Noel G Harvey

Yongji Fu

Ross Jacobson

Javier Alarcon

W Shannon Dillmore

Christopher C Herdman

Robert S Parker

Yiwen Zhang

William Shannon Dillmore

Terry J Amis

Adam Craig Curry

Ross W Jacobson

Richard J Klug

Elaine Mcvey

Frances Tong

Vince J Sullivan

Elaine Mc Vey

Alfed Joseph Harvey

Kirstin Weidemaier

Christopher Herdman

Disclosed herein are diagnostic assays using surface enhanced Raman spectroscopy (SERS)-active particles, including liquid-based assays; magnetic capture assays; microparticle-nanoparticle satellite structures for signal amplification in an assay; composite SERS-active particles useful for enhanced detection of targets; and sample tubes and processes for using the same.

Assays using surface-enhanced raman spectroscopy (SERS)-active particles

A system and method are provided for utilizing radiometric fluorescence detection to determine a glucose independent concentration value when measuring frequency bands that do not contain the system isosbestic point. Preferably two bands are chosen such that a first band is below the system isosbestic point, and a second band is above the system isosbestic point, and both points are sufficiently far from the frequency endpoints to maximize the signal to noise ratio.

System and method for diagnosing sensor performance using analyte-independent ratiometric signals

The present invention relates to a system and method for improving glucose sensor accuracy by utilizing multiple calibration methods and selecting the most accurate method depending on a consensus glucose concentration estimate. Embodiments of the present invention comprise the steps of performing at least one in vivo update of surrounding glucose to acquire glucose values; calculating multiple updated calibration estimates using the updated glucose values; calculating an initial consensus glucose estimate from sensor output using each updated calibration estimate; applying a smooth crossover function to the multiple calibration estimates based on the value of the initial consensus glucose estimate; and adding weights to the multiple calibration estimates to acquire a consensus glucose estimate.

System and method for using multiple sensor calibration methods

A medical fluid communication system is disclosed comprising a pump controller and a fluid detector. The fluid detector detects characteristics of the fluid and provides fluid measurements to the pump controller, which detects if the fluid is flowing in the medication delivery system. In the event fluid is not flowing due to an occlusion, the pump controller may attempt to resolve the occlusion or may provide a warning to a user that an occlusion is occurring.

System and method for detecting occlusions in a medication infusion system using pulsewise pressure signals

A lancing device integrated with a sensing strip and method of making and using the same are provided. A lance and analyte sensing strip are combined in a single, preferably disposable, device. In a preferred embodiment, a slot is provided in a support member so the lance can be engaged by a lance driver and driven into the skin producing a bodily fluid sample from a wound. The sensing area of the sensing strip is adjacent to the wound location reducing dexterity requirements for patients.

Integrated lancet and bodily fluid sensor

A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the optical conduit and sensing element may be housed within a cannulated bevel.

Fiber optic device for sensing analytes and method of making same

A closed loop therapy system for controlling a concentration of a substance, such as blood glucose concentration, in the body of a user. The system and method employ a sensor system that measures a glucose level in the body, a controller that uses the measured glucose levels to generate an output that can be used to automatically or manually control an intradermal insulin infusion system to set a constant or time-varying profile of target blood glucose concentrations in a user, and then infuse an appropriate amount of insulin into the body of the user so as to reach and maintain the target values of the blood glucose concentration.

System and method for initiating and maintaining continuous, long-term control of a concentration of a substance in a patient using a feedback or model-based controller coupled to a single-needle or multi-needle intradermal (ID) delivery device

A method for detecting oxygen in a test sample is provided, the method involving exposing a test sample and a control sample to sensor compositions having a luminescent compound capable of generating a signal indicative of oxygen depletion. The method further involves determining the strengths of such signals for the test sample versus the control sample, and using the difference to determine whether oxygen in the test sample is being consumed.

Methods for improving sensitivity of oxygen biosensors

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Chapel Hill, NC, United States of America

Steven Keith