Baxter International Inc.

Steven K Neuenfeldt

James H Brauker

Robert A Clarke

Mark Conrad Jones

Birendra K Lal

Daniel R Boggs

Shmuel Sternberg

Robin Gail Pauley

Laura A Martinson

Mark A Hoekwater

Atul R Khare

Donna L McLarty

Robin Lee Geller

David A Maryanov

Thomas Loudovaris

Scott Fredericksen

Joanne Daugird

Stephanie Shors

Irina A Rakin

Joseph B Loria

Victoria Carr-Brendel

A permeable structure forms a chamber to hold living cells. The structure includes a first permeable region surrounding at least a portion of the chamber having a conformation that, when implanted in host tissue, substantially blocks penetration of host cells into the chamber while permitting solute transport. The structure also includes a second permeable region overlying the first permeable region having a conformation that, when implanted in host tissue, forms a permeable interface with host tissue that permits solute transport. A third permeable region is located between the first and second permeable regions. The third region comprises a solution of polymer material formed in place between the first and second permeable regions. The third permeable region bonds the first and second permeable regions together. The third permeable region also has a conformation that, when implanted in host tissue, permits solute transport between the first and second permeable regions. The third, formed-in-place region bonds the first and second permeable regions together, providing a robust, laminated structure that resists delamination during implantation caused by cellular infiltration into discontinuous spaces between the first and second regions. The third, formed-in-place region can also have a conformation providing an immunoisolation effect. Furthermore, the permeability of the third, formed-in-place membrane is sufficient high that it does not adversely effect the permeability value desired for the overall multiple layer membrane structure.

Multiple-layer, formed-in-place immunoisolation membrane structures for

An implant assembly and methods for loading implant devices which avoids the accidental deposition of transplanted material or other contaminates on the exterior of the device during transportation, storage, and handling are disclosed. The implant assembly of the invention may be used with a large variety of implant devices for implanting a variety of materials such as cells, tissue or other materials into a host. The implant assembly includes an implant device having an elongated port and a first chamber for holding material for implantation and a container with a second chamber for holding the implant device. The container functions to maintain the sterility and protect the physical integrity of the implant device during loading, storage, cryopreservation and transportation and is removed immediately prior to implantation of the device. The container may optionally include liquid media for cellular growth, maintenance, cryostorage, or transportation purposes.

Implantation assembly

A method and apparatus for implanting cells in a host is provided. In an embodiment, an implant assembly for a host tissue is provided comprising wall means defining a chamber for holding cells for implantation, the wall means including means for forming a porous boundary between the host tissue and the implanted cells in the chamber, the pore size of the boundary being sufficient to isolate the implanted cells from the immune response of the host tissue, and port means for providing selective access to the chamber.

Ported tissue implant systems and methods of using same

An implant assembly for a host tissue is provided. The implant assembly comprises a pouch including wall means defining a chamber for holding a second member, the wall means including an outer vascularizing membrane having a conformation that results in growth of vascular structures by the host tissue close to an interface between the vascularizing membrane and host tissue. The assembly includes a second member that can be removably inserted in the chamber including an interior for receiving cells and wall means defining an immuno-isolating membrane that isolates the cells from the immune response of the host tissue.

Tissue implant systems

A method for implanting cells into a host tissue is provided. The method comprises the steps of: creating an implant assembly for holding cells including wall means for forming a porous boundary between the host tissue and the implanted cells in the device, the pore size of the boundary being sufficient to isolate the implanted cells from the immune response; implanting the assembly without the cells into a host tissue; and accessing an interior of the assembly to add the cells thereto.

Method for implanting tissue in a host

A method and apparatus for implanting cells in a host is provided. In an embodiment, an implant assembly for a host tissue is provided comprising wall means defining a chamber for holding cells for implantation, the wall means including means for foxing a porous boundary between the host tissue and the implanted cells in the chamber, the pore size of the boundary being sufficient to isolate the implanted cells from the immune response of the host tissue, and port means for providing selective access to the chamber.

An ultrasonic welding horn is provided that has an insert connected to the body of the horn proximal to the welding edge, the insert being dampened from the ultrasonic operating frequency by attaching it to the horn body at a nodal point that has little or no vibration during the operational vibrational mode of the horn. During a welding operation, the insert is positioned to secure living cell tissue that is between two plastic layers, preventing undesirable vibration of the cell tissue. The welding edge, which extends around the periphery of the insert, contacts the plastic layers around the cell tissue, welding a seal between the layers.

Ultrasonic welding horn with sonics dampening insert

Filter for I.V. administration

I.V. flow regulator

Growing community of inventors

Vernon Hills, IL, United States of America

Steven K Neuenfeldt