Bausch-lomb Incorporated

Steven K MacLeod

Erning Xia

Craig M Cody

James Donald Hayes

Tammy J Kleiber

Donald L Herber

Daniel J Stein

Michael E Allen

A process for producing a pharmaceutical suspension that comprises an active pharmaceutical ingredient ('API') having low solubility, the process comprises: (a) preparing a first solution comprising a carboxy-containing vinyl polymer and a solvent; and (b) adding a compound of the API to said first solution under conditions of high-shear mixing for a time from about 5 minutes to about 5 hours, said compound being soluble in said solvent, thereby producing a suspension of particles of said API in a composition comprising said carboxy-containing vinyl polymer; wherein a concentration of said API in said suspension is higher than a solubility of said API in said solvent. The present invention also provides a suspension produced by such process.

Method for preparing suspensions of low-solubility materials

A pharmaceutical formulation that is effective in adversely affecting the viability of microorganisms or in inhibiting their growth and that provides better safety and/or comfort to the users comprises a polysaccharide, a source of hydrogen peroxide, and an anti-oxidant. The formulation can further comprise a chelating agent and/or an ophthalmically active agent for treating or controlling a disease or disorder of the eye. The formulation may be used to treat, clean, disinfect, store, wet, or rewet contact lenses.

Pharmaceutical formulations comprising stabilized polysaccharides and source of hydrogen peroxide

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Henrietta, NY, United States of America

Steven K MacLeod