Isotron, Inc.

Steven K Jacobs

David Halpern

The invention described herein comprises a method of treating a subject having a disorder characterized by the presence of one or more tumors comprising inserting a miniaturized concentrated neutron emitting source into said tumor(s) for a time sufficient to irradiate the cells of the tumor(s). The invention method can be employed in the treatment of both malignant and non-malignant tumors and is especially useful in the treatment of malignant tumors found in the brain, prostate, and other internal organs. A preferred neutron source is californium-252. The majority of the tumor can be surgically removed prior to insertion of the neutron emitting source. In a further embodiment of the invention, a neutron capture compound can be localized to the cells of the tumor prior to insertion of the miniaturized neutron emitting source in order to augment the effects of neutron therapy.

Methods for treating solid tumors using neutron therapy

A method of treating a subject having a disorder characterized by a tumor performed by inserting a miniaturized concentrated neutron emitting source into the tumor to irradiate the cells of the tumor. The method is useful in treating malignant and non-malignant tumors and is especially useful in the treating of tumors of the brain, prostate, cervix and other internal organs. A preferred neutron source is californium-252. The tumor may be surgically treated prior to insertion of the neutron emitting source. A neutron capture compound may be localized to the cells of the tumor prior to insertion of the source to augment the effects of neutron therapy.

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New Canaan, CT, United States of America

Steven K Jacobs