Magainin Pharmaceuticals, Inc.

Genaera Corporation

Steven Jones

William Alvin Kinney

Michael A Zasloff

Harold Meckler

Ann Shinnar

Meena N Rao

Michel Bulliard

Xuehai Zhang

Nancy Lee

Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.

Treatment of neovascularization disorders with squalimine

A method is described for stereoselectively reducing an unsaturated alkyl ketone substituent attached to a fused ring base. In this method, the unsaturated alkyl ketone reacts with a chiral oxazaborolidine reagent. This reaction stereoselectively reduces the unsaturated alkyl ketone to an unsaturated alkyl alcohol. The unsaturated alkyl alcohol can be further reduced, if desired, to produce a saturated alkyl alcohol. The fused ring base can be, for example, a steroid ring base or a base of a vitamin D analog. The process in accordance with the invention can be used with an alkeneone substituent (e.g., a 22-ene-24-one substituent) or an alkyneone substituent (e.g., a 22-yne-24-one substituent) on a steroid ring base to make squalamine or other useful aminosterol compounds and intermediates for making aminosterol compounds.

Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds

Certain aminosterol compounds and pharmaceutical compositions including

An aminosterol compound according to the following formula: ##STR1## wherein: R.sub.1 is a member selected from the group of: ##STR2## R.sub.2 is H or OH; R.sub.3 is H or OH;

Aminosterol ester compounds

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West Chester, PA, United States of America

Steven Jones