Vertex Pharmaceuticals, Inc.

Steven Jones

Mark Willem Ledeboer

Francesco Gerald Salituro

Tiansheng Wang

Paul S Charifson

Francois Maltais

Luc J Farmer

Huai Gao

Emanuele Perola

John J Court

Upul Keerthi Bandarage

Chao Lin

Randy Scott Bethiel

Hongbo Deng

John P Duffy

Brian Ledford

Wenxin Gu

Joseph M Kennedy

Michael P Clark

Ioana Davies

M Woods Wannamaker

Dylan H Jacobs

Randal Byrn

Ursula A Germann

Yi Zhou

Min Jiang

Ann Dak-Yee Kwong

Ales Medek

Valdas Jurkauskas

Yi Shi

Michael Waldo

Praveen Mudunuri

Ioana Drutu

Kwame Wiredu Nti-Addae

Sarah Robertson

Mohammed Asmal

Wanjung Tsai

Simon Adam O'Neil

John Gregg Van Alsten

Dainius Macikenas

Randal Bym

Sarah Marie Robertson

Luc Farmer

Woods M Wannamaker

Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

Inhibitors of influenza viruses replication

Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: are Form A of HCl salt of Compound (1).&#xbd;HO, Form F of HCl salt of Compound (1).3HO, Form D of HCl salt of Compound (1), Form A of Compound (1), and Form A of tosylate salt of Compound (1). Such polymorphic forms are employed for treating influenza, inhibiting the replication of influenza viruses, or reducing the amount of influenza viruses in a biological sample or in a subject.

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Hyde Park, MA, United States of America

Steven Jones