International Business Machines Corporation

University of Minnesota

Boston Scientific Scimed, Inc.

Globalfoundries Inc.

US Government As Represented by the Secretary of the Army

Steven John Koester

Jack Oon Chu

Devendra K Sadana

Mukta G Farooq

Subramanian Srikanteswara Iyer

Amlan Majumdar

Sampath Purushothaman

Roy Rongqing Yu

Robert Hannon

Josephine B Chang

Leland Chang

Fei Liu

Xue Zhen

Philippe Pierre Joseph Buhlmann

Jeffrey W Sleight

Keith E Fogel

Alfred Grill

John Albrecht Ott

Edward William Kiewra

Albert M Young

Khalid EzzEldin Ismail

Justin Theodore Nelson

Ghavam G Shahidi

Qiqing Christine Ouyang

Solomon Assefa

Kuan-Neng Chen

Stephen W Bedell

Kevin K Chan

Isaac Lauer

Cyril Cabral, Jr

Katherine Lynn Saenger

Joel Pereira De Souza

Wilfried Haensch

Jin Cai

Sarunya Bangsaruntip

Shahab Siddiqui

Jeremy Daniel Schaub

Christopher Carr Parks

Patricia May Mooney

Sang-Hyun Oh

Gabriel Konrad Dehlinger

Richard Hammond

Huilong Zhu

Guy M Cohen

Michael S Gordon

Christian Lavoie

Kenneth Parker Rodbell

Paul Michael Solomon

Jeng-Bang Yau

Eduard Albert Cartier

Renee Tong Mo

Gregory J Sherwood

Yurii A Vlasov

Vishnubhai Vitthalbhai Patel

Brian L Ji

Roy Arthur Carruthers

Ronnen Andrew Roy

Dinkar Virendra Singh

Kingsuk Maitra

Yuri A Vlasov

Bernd-Ulrich H Klepser

Daniel C Edelstein

Michael A Guillorn

Davood Shahrjerdi

Kern Rim

Martin Michael Frank

Conal Eugene Murray

Stephen Mark Rossnagel

Robert L Wisnieff

Ho-Cheol Kim

Michael John Hargrove

Jean Fompeyrine

Yanning Sun

Klaus D Beyer

William Dinan Hinsberg

Huiling Shang

Norma Edith Sosa Cortes

Michael C McAlpine

David J Webb

Feng-Yi Huang

Qiging Ouyang

Jeffrey W Sleights

Brian J Li

Yao Zhang

Joshua Uzarski

Ruitao Su

Qun Su

Paul M Soloman

Venkata Raghava Saran Kumar Chaganti

Blair K Troudt

Amlan Majumdat

Sampath Porushothaman

Embodiments herein relate to systems and methods for utilizing hysteresis as a mechanism of analysis of a sample. A system for analyzing a fluid sample is included having a controller circuit and a chemical sensor element. The chemical sensor element can include one or more discrete binding detectors that can include one or more graphene varactors. The system can include measurement circuitry having an electrical voltage generator configured to generate an applied voltage at a plurality of voltage values to be applied to the one or more graphene varactors. The system can include a measurement circuit having a capacitance sensor configured to measure capacitance of the discrete binding detectors resulting from the applied voltage. The system for analyzing the fluid sample can be configured to measure hysteresis effects related to capacitance versus voltage values obtained from the one or more graphene varactors. Other embodiments are also included herein.

Systems utilizing graphene varactor hysteresis effects for sample characterization

Embodiments herein relate to chemical sensors based on the non-covalent surface modification of graphene with compounds containing hydrazine or hydroxylamine functional groups for the detection of aldehyde and ketone-bearing analytes. In an embodiment, a medical device is included having a graphene varactor included a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through electrostatic interactions between a partial positive charge on hydrogen atoms of one or more hydrocarbons of the self-assembled monolayer and a π-electron system of graphene. The self-assembled monolayer can include one or more compounds having one or more hydrazine groups or hydroxylamine groups, substituted hydrazine or hydroxylamine groups, or derivatives thereof. Other embodiments are also included herein.

Aldehyde and ketone receptor modification of graphene

A dielectrophoretic (DEP) sensor includes a graphene electrode adjacent a channel for confining a target particle in a liquid, a surface probe attached to a surface of the graphene electrode, the surface probe having a selective reaction with the target particle, and a voltage source electrically connected to the graphene electrode and configured to apply a voltage to the graphene electrode to cause DEP trapping of the target particle at the graphene electrode.

Graphene-based dielectrophoresis sensor and method

Chemical sensors, devices and systems including the same, and related methods are disclosed. In an embodiment, a medical device is included having a graphene varactor including a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through non-covalent interactions between the self-assembled monolayer and a π-electron system of graphene. The self-assembled monolayer includes one or more pillarenes, substituted pillarenes, calixarenes, substituted calixarenes, peralkylated cyclodextrins, substituted peralkylated cyclodextrins, pyrenes, or substituted pyrenes, or derivatives of each. Other embodiments are also included.

Non-covalent modification of graphene-based chemical sensors

A varactor may include a gate electrode; a graphene layer; and a ferroelectric layer between the gate electrode and the graphene layer.

Graphene varactor including ferroelectric material

Embodiments include chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is provided. The medical device can include a graphene varactor, including a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through electrostatic interactions between a partial positive charge on hydrogen atoms of one or more hydrocarbons of the self-assembled monolayer and a π-electron system of graphene. The self-assembled monolayer can include one or more substituted porphyrins or substituted metalloporphyrins, or derivatives thereof. Other embodiments are also included herein.

Chemical sensors with non-covalent, electrostatic surface modification of graphene

A printed structure including a plurality of overlying layers of elongate polymeric filaments stacked on a surface of a substrate. The elongate polymeric filaments are stacked on each other along their lengths to form a liquid impermeable, self-supporting wall. The liquid impermeable self-supporting wall forms a wall angle of about 30&#xb0; to about 90&#xb0; with respect to a plane of the surface of the substrate.

Additively manufactured self-supporting microfluidics

Devices, systems, and methods for applying a dielectrophoretic force on a particle include: a cell defining at least one channel for confining the particle; and a first electrode and a second electrode electrically isolated from the first electrode, at least one of the first and second electrodes being formed from a two-dimensional (2D) material providing an atomically sharp edge. The first and second electrodes are arranged sufficiently close to one another and sufficiently close to the channel such that application of a sufficient voltage across the first and second electrodes generates an electric field in at least part of the channel, the electric field having an electric field gradient sufficient to apply the dielectrophoretic force on the particle in the channel.

Electrodes formed from 2D materials for dielectrophoresis and systems and methods for utilizing the same

Embodiments herein include a kinetic response system for measuring analyte presence on a chemical sensor element. The chemical sensor element includes one or more discrete binding detectors, each discrete binding detector including a graphene varactor. The kinetic response system includes a measurement circuit having an excitation voltage generator for generating a series of excitation cycles over a time period. Each excitation cycle includes delivering a DC bias voltage to the discrete binding detectors at multiple discrete DC bias voltages across a range of DC bias voltages. The kinetic response system includes a capacitance sensor to measure capacitance of the discrete binding detectors resulting from the excitation cycles. The kinetic response system includes a controller circuit to determine the kinetics of change in at least one of a measured capacitance value and a calculated value based on the measured capacitance over the time period. Other embodiments are also included herein.

Systems and methods for measuring kinetic response of chemical sensor elements

An electrical device includes at least one graphene quantum capacitance varactor. In some examples, the graphene quantum capacitance varactor includes an insulator layer, a graphene layer disposed on the insulator layer, a dielectric layer disposed on the graphene layer, a gate electrode formed on the dielectric layer, and at least one contact electrode disposed on the graphene layer and making electrical contact with the graphene layer. In other examples, the graphene quantum capacitance varactor includes an insulator layer, a gate electrode recessed in the insulator layer, a dielectric layer formed on the gate electrode, a graphene layer formed on the dielectric layer, wherein the graphene layer comprises an exposed surface opposite the dielectric layer, and at least one contact electrode formed on the graphene layer and making electrical contact with the graphene layer.

Ultra-compact, passive, wireless sensor using quantum capacitance effect in graphene

Embodiments include chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is provided. The medical device can include a graphene varactor, including a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through electrostatic interactions between a partial positive charge on hydrogen atoms of one or more hydrocarbons of the self-assembled monolayer and a it-electron system of graphene. The self-assembled monolayer can include one or more substituted porphyrins or substituted metalloporphyrins, or derivatives thereof. Other embodiments are also included herein.

Embodiments herein relate to chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is included. The medical device can include a graphene varactor. The graphene varactor can include a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through &#x3c0;-&#x3c0; stacking interactions. The self-assembled monolayer can provide a Langmuir theta value of at least 0.9. The self-assembled monolayer can include polycyclic aromatic hydrocarbons, tetraphenylporphyrins or derivatives thereof, metallotetraphenylporphyrins, or aromatic cyclodextrins. Other embodiments are also included herein.

Chemical sensors with non-covalent surface modification of graphene

Ultra-compact, passive, varactor-based wireless sensor using quantum capacitance effect in graphene

Growing community of inventors

Ossining, NY, United States of America

Steven John Koester