Gen-probe, Inc.

Massachusetts Institute of Technology

Steven Joel Brown

Nanibhushan Dattagupta

Yathi M Naidu

Stephen J Lippard

Patti Jean Kellett

John M Essigmann

Jeffrey H Toney

Suzanne L Bruhn

Brian A Donahue

Pieter M Pil

The present invention relates to methods of treating disease-associated cellular proliferation using oligonucleotides. In particular, it relates to the use of oligonulceotides which are substantially complementary to interleukin-6 receptor mRNA sequences. In the form of pharmaceutical compositions, these oligonucleotides are suitable for administration to human subjects for the treatment of abnormal cellular proliferation due to such diseases as cancer, autoimmune disorders and viral infection.

Oligonucleotides and methods for inhibiting cellular proliferation

Method for inhibiting cellular proliferation using antisense

Methods disclosed herein capitalize on the ability of DNA Structure Specific Recognition Proteins (SSRPs) to bind to genomic lesions formed by chemotherapeutic agents, particularly cisplatin-type agents. Methods are provided for predicting whether an agent that damages DNA will also be cytotoxic, and for predicting whether particular eukaryotic cells will be susceptible to killing by a genotoxic drug. A screening method is provided for identifying new genotoxic drugs that produce SSRP-recognized lesions in DNA. Methods also are provided for sensitizing particular eukaryotic cells to killing by chemotherapeutic agents, particularly cisplatin-type drugs.

Uses for DNA structure-specific recognition protein

Growing community of inventors

La Jolla, CA, United States of America

Steven Joel Brown