Northwest Biotherapeutics, Inc.

Steven J Monahan

Alton L Boynton

Paul C Harris

Marnix L Bosch

Patricia A Lodge

Allen Turner

The present invention provides tangential flow filtration devices and methods for enriching a heterogenous mixture of blood constituents for leukocytes by removal of non-leukocyte blood constituents. In one particular embodiment the device can provide a composition enriched in monocytes.

Tangential flow filtration devices and methods for leukocyte enrichment

The present invention provides tangential flow filtration devices and methods for enriching a heterogeneous mixture of blood constituents for leukocytes by removal of non-leukocyte blood constituents. In one particular embodiment the device can provide a composition enriched in monocytes. One embodiment includes a remover unit () having a crossflow chamber () separated by a microporous filter () from a filtrate chamber (), the remover unit () also having a tangential flow inlet (), a fluid outlet () for a fluid enriched in leukocytes and a filtrate outlet ().

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Kenmore, WA, United States of America

Steven J Monahan