Hoechst Marion Roussel

Merrell Dow Pharmaceuticals

Steven J Busch

Paul S Wright

Roger A Parker

Mark T Yates

Kim S Chen

Michael L Edwards

Mark J Vaal

Alan D Cardin

James E Matt

Masayuki Mano

James E Matt, Jr

The present invention provides compounds of the formula ##STR1## wherein R is hydrogen or --C(O)--(CH.sub.2).sub.m --Q wherein Q is hydrogen or --COOH and m is an integer 1, 2, 3 or 4;

Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant

The present invention provides compounds of the formula ##STR1## wherein X is selected from the group consisting of ##STR2## Y is thio, oxy or a methylene group; Z is hydrogen or --C(O)--(CH.sub.2).sub.m --Q wherein Q is hydrogen or --COOH and m is an integer 1, 2, 3 or 4;

Substituted phenols and thiophenols useful as antioxidant agents

Methods useful for inhibiting VCAM-1 and for treating chronic inflammatory conditions in a patient in need thereof are disclosed comprising administering to the patient effective amounts of a compound of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently a C.sub.1 -C.sub.6 alkyl group;

Method of inhibiting vascular cell adhesion molecule-1 and treating

This invention relates to compounds of the formula ##STR1## wherein R.sub.1 and R.sub.6 are each independently C.sub.1 -C.sub.6 alkyl;

Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents

The oligomers of the present invention are polyureas or polyamides having a number average molecular weight of &lt;10,000. These oligomers are water-soluble, have a rigid backbone with a predictable anion spacing, and are pharmaceutically-acceptable. The oligomers are useful for inhibiting the proliferation of smooth muscle cell.

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West Chester, OH, United States of America

Steven J Busch