Hewlett-packard Development Company, L.p.

Steven J Barcelo

Zhiyong Li

Gary A Gibson

Ansoon Kim

Ning Ge

Zhang-Lin Zhou

Huei Pei Kuo

Anita Rogacs

Alexandre M Bratkovski

Shih-Yuan Wang

Mineo Yamakawa

Helen Ann Holder

Lihua Zhao

Charles Santori

Raghuvir N Sengupta

Viktor Shkolnikov

Kevin Dooley

Milo Overbay

A luminescence-enhancement system can include a luminescence-enhancement sensor having a substrate and a group of nanofingers with individual nanofingers that can be flexible and include a support end attached to the substrate, a distal tip positioned distally with respect to the substrate, and a middle portion between the support end and the distal tip. A coating of a metal or metal alloy can be applied to the substrate and the distal tip that is conductively continuous. The middle portion can be devoid of the coating or the coating at the middle portion is conductively discontinuous. A liquid ejector can be present and can include a jetting nozzle to eject a liquid droplet having a volume of 2 pL to 10 &#x3bc;L. The group of nanofingers and the jetting nozzle can be positionable relative to one another for the droplet to be deposited on the group of nanofingers.

Luminescence-enhancement systems

A microporous structure includes an array of nano wires and a coating about the nano wires of the array. The coating defines pores between the nano wires.

Nano wire microporous structure

A spectroscopic device is provided. The spectroscopic device includes a plurality of design groups on a substrate. Each design group includes a plurality of collapsed groups separated by bare regions of substrate, wherein the edges of each design group is configured to enhance the pinning of a solvent drying line at the edge of the design group. Each collapsed group comprises at least 2 flexible columnar structures, and each flexible columnar structure comprises a metal cap.

Spectroscopic device including design groups

A surface enhanced luminescence analyte nano pillar stage may include a substrate, an array of closable pillars extending from the substrate and a fluid supply connected to the array of pillars. The fluid supply is to at least partially replenish fluid amongst the pillars of the array that has evaporated to maintain a level of the fluid amongst the pillars of the array below tops of the pillars.

Surface enhanced luminescence nano pillar stage

A surface enhanced luminescence (SEL) sensing stage may include a matrix and plasmonically active nanostructures retained within the matrix, wherein no greater than 10% of the plasmonically active nanostructures consist of a single unagglomerated plasmonically active nano particle.

Matrix with plasmonically active nano structures

A microfluidic chip may include a substrate, chamber supported by the substrate, a sacrificial material in the chamber, a spectroscopically active nano particle assembly anchored within the chamber by the sacrificial material and a fluid supply port connected to the chamber. Each spectroscopically active nano particle assembly may include a cluster of nanoparticles.

Microfluidic chip with anchored nano particle assembly

In an example implementation, a substance detection method includes sensing for fluid in a chamber of a substance detection device. When fluid is sensed in the chamber, the method includes sensing again for fluid in the chamber. When no fluid is sensed in the chamber, the method includes initiating a substance detection process.

Substance detection

Provided in one example is an analyte detection package that includes a chamber, a surface-enhanced luminescence analyte stage within the chamber, and a lens integrated as part of the package to focus radiation onto the analyte stage.

Analyte detection package with integrated lens

In one example, a structure for surface enhanced Raman spectroscopy includes a cluster of metal nanoparticles in a hole.

Structures for surface enhanced Raman

In an example implementation, a substance detection device includes a chamber with chamber walls, a chamber top, and a chamber bottom. A substrate comprises imprinted nanostructures positioned within the chamber, and the substrate is coupled to the chamber walls to form the chamber bottom. An inert gas is sealed within the chamber.

Substance detection device

In one example, an analyte detection package includes a substrate, surface-enhanced luminescence (SEL) structures extending from the substrate and a low wettability housing. The SEL structures have a first wettability for a given liquid. The low wettability housing extends from the substrate to form a chamber between the housing of the substrate about the SEL structures to receive an analyte containing solution. The housing has an inner surface adjacent the chamber, wherein the inner surface has a second wettability for the given liquid less than the first wettability.

Analyte detection package housing

Devices to detect a substance and methods of producing such a device are disclosed. An example device to detect a substance includes a housing defining a first chamber and a substrate coupled to the housing. The substrate includes nanostructures positioned within the first chamber. The nanostructures are to react to the substance when exposed thereto. The device includes a first heater positioned within the first chamber. The heater is to heat at least a portion of the substance to ready the device for analysis.

Devices to detect a substance and methods of producing such a device

In an example implementation, a substance detection device includes a substrate having nanoimprinted chamber walls and nanostructures. The chamber walls define a chamber and the nanostructures are positioned within the chamber to react to a substance introduced into the chamber. A two-dimensional (2D) orifice plate is affixed to the chamber walls and forms a top side of the chamber.

Provided in one example is an analyte detection apparatus that includes surface enhanced luminescence (SEL) structure. A dielectric layer underlies the SEL structure. An electric field generating base underlies the dielectric layer. The electric field generating base is to apply an electric field about the SEL structures to attract charged ions to the SEL structures.

Surface enhanced luminescence electric field generating base

A method for forming a surface-enhanced fluorescence spectroscopy (SEFS) apparatus may include depositing a plurality of surface-enhanced spectroscopy (SES) elements onto respective tips of a plurality of nano-fingers, wherein the nano-fingers are arranged in sufficiently close proximities to each other to enable the tips of a group of adjacent nano-fingers to come into sufficiently close proximities to each other to enable the SES elements on the tips to trap fluorescent probe molecules that are to bind with target molecules when the nano-fingers are partially collapsed.

Growing community of inventors

Mountain View, CA, United States of America

Steven J Barcelo