Alcon Laboratories, Inc.

Alcon Manufacturing, Ltd.

Steven Howard Gerson

Wesley Wehsin Han

Ernesto J Castillo

Thomas R Dean

Yusuf Ali

Rajni Jani

Fatty acid/amino acid soaps are used to enhance antimicrobial effectiveness in topically administrable pharmaceutical compositions containing at least one active ingredient, a cationic preservative and an anionic polyelectrolyte, such as a carboxyvinyl polymer, xanthan gum, polystyrene sulfonic acid polymer or cationic exchange resin.

Use of certain fatty acid/amino acid soaps to enhance antimicrobial effectiveness of topically administrable pharmaceutical compositions

Fatty acid/amino acid soaps are used in conjunction with an antifungal acid and a chelating agent as a new preservative system for topically administrable pharmaceutical compositions.

Preservative system for topically administrable pharmaceutical compositions containing a fatty acid/amino acid soap

Anionic surfactants are used in conjunction with an antifungal acid and a chelating agent to preserve topically administrable pharmaceutical compositions without the need for a conventional preservative such as benzalkonium chloride.

Preservative system for topically administrable pharmaceutical compositions

Anionic amino acid based surfactants are used to enhance antimicrobial effectiveness in topically administrable pharmaceutical compositions containing at least one active ingredient, a cationic preservative and an anionic polyelectrolyte, such as carboxyvinyl polymers, xanthan gum, polystyrene sulfonic acid polymers and cationic exchange resins.

Use of certain anionic amino acid based surfactants to enhance

The present invention is directed to topical ophthalmic formulations of carbonic anhydrase inhibitors and polyethoxylated derivatives of castor oil. Methods for using the formulations for treating and controlling glaucoma and ocular hypertension are also disclosed.

Topical ophthalmic carbonic anhydrase inhibitor formulations

Disclosed are esters and amides of (+) suprofen, substantially free of the corresponding enantiomorp, (-) suprofen, having enhanced delivery characteristics on topical administration to the eye; also disclosed are pharmaceutical compositions comprising such (+) suprofen derivatives and methods of using them when indicated to achieve an anti-inflammatory effect on topical delivery to the eye.

(+) Suprofen esters and amides as opthalmic anti-inflammatory agents

Disclosed are esters and amides of suprofen having enhanced delivery characteristics on topical administration to the eye; also disclosed are pharmaceutical compositions comprising such suprofen derivatives and methods of using them when indicated to achieve an anti-inflammatory effect on topical delivery to the eye.

Suprofen esters and amides as ophthalmic anti-inflammatory agents

The hydrabamine and benzathine salts of cefamandole are useful in aqueous ophthalmic compositions which have good stability and shelf life.

Sparingly soluble salts of cefamandole, and ophthalmic compositions

Fatty acid salts of betaxolol, a cardioselective beta-blocker, and ophthalmic compositions containing these salts are described. These new salts have an aqueous solubility significantly less than that of betaxolol hydrochloride. This relatively poor aqueous solubility enables the salts to be slowly released from a suitable ophthalmic vehicle when placed in the aqueous environment of the eye. The salts also exhibit a significantly lower incidence of ocular irritation, as compared to ophthalmic solutions containing betaxolol hydrochloride.

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Fort Worth, TX, United States of America

Steven Howard Gerson