Gilead Sciences, Inc.

Steven H Krawczyk

Choung U Kim

William John Watkins

Hyung-Jung Pyun

Lawrence R McGee

Aesop Cho

Thorsten A Kirschberg

James Ming Chen

Lee Shun Chong

Maria Fardis

Norbert W Bischofberger

Xiaowu Chen

Richard L Mackman

Peter H Nelson

Jennifer R Zhang

Adrian S Ray

Kuei-Ying Lin

Wenjin Yang

David A Oare

Sundaramoorthi Swaminathan

Carina E Cannizzaro

Lijun Zhang

Constantine G Boojamra

Alan X Huang

David Y Markevitch

Christopher P Lee

Michael J Postich

Vidya K Prasad

Manoj C Desai

William A Lee

Haolun Jin

Ralph F Hirschmann

Rosemarie Sherlock

Craig S Gibbs

The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.

Therapeutic phosphonate compounds

The invention provides compounds with activity against infectious diseases. The compounds of the invention may inhibit retroviral reverse transcriptases and thus inhibit the replication, of the virus. The compounds of the invention may be useful for treating human patients infected with a human retrovirus, such as human immunodeficiency virus (strains of HIV-l or HIV-2) or human T-cell leukemia virus (HTLV-1 or HTLV-II) which results in acquired immunodeficiency syndrome (AIDS) and/or related diseases. Representative of the invention is a compound of the following formula, with the substituents defined herein: 

Nucleobase phosphonate analogs for antiviral treatment

The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Anti-cancer phosphonate analogs

The invention is related to phosphorus substituted compounds with activity for treating metabolic diseases and/or disorders, e.g., diabetes and hypercholesterolemia, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Phosphonate analogs for treating metabolic diseases

Tri- and tetra substituted thiepane compositions having use as immunogens, therapeutics, diagnostics and for other industrial purposes are disclosed. The compositions inhibit proteolytic activity of viral enzymes and are useful for the inhibition of such enzymes as well as in assays for the detection of such enzymes. Embodiments in which antigenic polypeptides are bonded to the compositions are useful in raising antibodies against the thiepane haptens or the polypeptide. Labeled thiepanes of this invention are useful as diagnostic reagents.

Thiepane compounds

Tri- and tetra substituted thiepane and compositions having use as immunogens, therapeutics, diagnostics and for other industrial purposes are disclosed. The compositions inhibit proteolytic activity of viral enzymes and are useful for the inhibition of such enzymes as well as in assays for the detection of such enzymes. Embodiments in which antigenic polypeptides are bonded to the compositions are useful in raising antibodies against the thiepane haptens or the polypeptide. Labeled thiepanes of this invention are useful as diagnostic reagents.

Growing community of inventors

San Carlos, CA, United States of America

Steven H Krawczyk