The United States of America, As Represented by the Secretary, Department of Health and Human Services

Beckman Coulter, Inc.

Steven H Fischer

Jang B Rampal

Joseph A Kovacs

Henry Masur

Qin Mei

Gary A Fahle

Vee J Gill

Patricia S Conville

Shengning Huang

A method for species-specific identification of aspecies is provided. Also disclosed is a method for identifying the species ofpresent in a sample. A device is disclosed for the detection of-specific oligonucleotides are also disclosed, as are kits.

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Particularly sensitive techniques for the detection of in clinical samples are disclosed. These techniques relate to the PCR amplification and/or detection of human- major surface glycoprotein (MSG) gene sequences. Also disclosed are seven novel genes encoding human- MSG, and the proteins encoded for by these genes. These genes provide proof that human- MSG is encoded for by a highly conserved gene family, and that the conesponding proteins have a very highly conserved region of about 100 amino acids near their C-terminal end. This highly conserved carboxy-terminal region has a significantly different sequence than that found in rat-derived MSG.

Identification of a region of the major surface glycoprotein (MSG) gene of human Pneumocystis carinii

Growing community of inventors

Rockville, MD, United States of America

Steven H Fischer