E.i. Dupont De Nemours and Company

Other

Pioneer Hi-bred International, Inc.

Fmc Corporation

Steven Gutteridge

Rebecca E Cahoon

J Antoni Rafalski

Anthony John Kinney

Howard Glenn Damude

Michael W Lassner

Yong Tao

Timothy Caspar

Daniel Cordova

Lihong Wu

Leslie T Harvell

James J Rauh

Andrew Edmund Taggi

James Francis Bereznak

Rejane M Smith

Jeffrey Keith Long

Vann Gregory

Linda A Castle

Karlene H Butler

Emil M Orozco, Jr

Bruce Aaron Diner

Matthew James Campbell

Daniel Siehl

William E Wolf

Sean M Bertain

Ravisekhara Pochimireddy Reddy

Henrik Albert

Steven Vollmer

Moumita Kar

Kay Walter

Mary Kolean Koeppe

Gary L Peterson

Daniel L Siehl

Johan A J Desaeger

Kevin Eugene Diehl

Kevin Ray Oldenburg

John Lawrence Andreassi, Ii

Timothy Casper

Johan A Desaeger

Compositions and methods comprising polynucleotides and polypeptides having ALS activity and tolerance to at least one ALS inhibitor are provided. In specific embodiments, the sequence has an increased preference for 2-ketobutyrate, when compared to an appropriate control, such as for example, HRA, and/or a preference for 2-ketobutyrate similar to a native ALS. Further provided are nucleic acid constructs, plants, plant cells, explants, seeds and grain having the ALS inhibitor tolerant sequences. Various methods of employing the ALS inhibitor tolerant sequences are provided. Such methods include methods for producing an ALS inhibitor tolerant plant, plant cell, explant or seed and methods of controlling weeds in a field containing a crop employing the plants and/or seeds disclosed herein.

Methods and compositions involving ALS variants with native substrate preference

Disclosed is a fungicidal composition comprising (a) at least one compound selected from the compounds of Formula 1, N-oxides, and salts thereof,  Also disclosed is a method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof, or to the plant seed, a fungicidally effective amount of a compound of Formula 1, an N-oxide, or salt thereof (e.g., as a component in the aforesaid composition). Also disclosed is a composition comprising: (a) at least one compound selected from the compounds of Formula 1 described above, N-oxides, and salts thereof; and at least one invertebrate pest control compound or agent.

Fungicidal pyrazoles and their mixtures

Disclosed is a fungicidal composition comprising (a) at least one compound selected from the compounds of Formula 1, N-oxides, and salts thereof, wherein R, R, R, R, Rand Rare as defined in the disclosure;and (b) at least one additional fungicidal compound. Also disclosed is a method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof, or to the plant seed, a fungicidally effective amount of a compound of Formula 1, an N-oxide, or salt thereof (e.g., as a component in the aforesaid composition). Also disclosed is a composition comprising: (a) at least one compound selected from the compounds of Formula 1 described above, N-oxides, and salts thereof; and at least one invertebrate pest control compound or agent.

Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, wherein Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention. Also disclosed are methods for controlling a phytophagous nematode comprising contacting the nematode or its environment with a nematocidally effective amount of a compound of Formula 1 wherein L is &#x2014;C(R)R&#x2014;C(R)R; and A, Z, R, R, n, G and Q are as defined in the disclosure.

Fungicidal heterocyclic carboxamides

The genes encoding ryanodine receptor homologs have been characterized from multiple insect families. The genes and their corresponding polypeptides have a number of uses including but not limited to the development of screens to identify insecticidally active compounds. Methods are outlined for overcoming toxic effects of expressing recombinant proteins in host cells.

Isolation and use of ryanodine receptors

The genes encoding ryanodine receptor homologs have been characterized from multiple insect families including lepidopteran tobacco budworm (), homopteran green peach aphid (), corn plant hopper (), cotton melon aphid () and fruitfly (). The full-length genes have been isolated, cloned and amplified in bacterial cells. Expression in insect cells shows that the recombinant protein folds into a functional calcium release channel. The genes and their corresponding polypeptides have a number of uses including, but not limited to, the isolation of other pest ryanodine receptors, the development of screens to identify insecticidally active compounds, use of fragments of genes as pesticides, fragments of protein for antibody production, fragments of protein for determination of the structure of insecticide binding sites, and identification of insecticides that disrupt the calcium balance in cells through other messengers that interact with the receptor calcium release mechanism. Methods are outlined for overcoming toxic effects of expressing recombinant proteins in host cells.

Ryanodine receptor polypeptides

This invention relates to isolated nucleic acid fragments encoding pantothenate synthetases. The invention also relates to the construction of chimeric genes encoding all or a portion of the pantothenate synthetases, in sense or antisense orientation, wherein expression of the chimeric genes results in production of altered levels of the pantothenate synthetases in transformed host cells.

Plant genes encoding pantothenate synthetase

Nucleic acids encoding ryanodine receptors

This invention relates to isolated nucleic acid fragments encoding phosphoribosylanthranilate isomerases, a tryptophan biosynthetic enzyme. The invention also relates to the construction of a chimeric gene comprising the nucleic acid fragment, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the phosphoribosylanthranilate isomerase in a transformed host cell.

Polynucleotides encoding phosphoribosylanthranilate isomerase

This invention relates to an isolated nucleic acid fragment encoding a metalloprotease, more specifically peptide deformylase. The invention also relates to the construction of a recombinant DNA construct encoding all or a portion of peptide deformylase, in sense or antisense orientation, wherein expression of the recombinant DNA construct results in production of altered levels of peptide deformylase in a transformed host cell.

Peptide deformylase

This invention relates to an isolated nucleic acid fragment encoding an aminolevulinic acid biosynthetic enzyme. The invention also relates to the construction of a chimeric gene encoding all or a portion of the aminolevulinic acid biosynthetic enzyme, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the aminolevulinic acid biosynthetic enzyme in a transformed host cell.

Polynucleotides encoding aminolevulinic acid biosynthetic enzymes

Growing community of inventors

Wilmington, DE, United States of America

Steven Gutteridge