Novartis Ag

Ottawa Health Research Institute

Novartis Animal Health Us, Inc.

Atlantic Cancer Research Institute

New England Peptide, Inc.

Aqua Health (europe) Limited

Steven Gareth Griffiths

Rachael Jane Ritchie

Joel Heppell

Kira Salonius

Nathalie C Simard

Scott Edwin Lewis

Rachel Jane Ritchie

The present application is directed to a peptides comprising an a-helix forming-amino acid sequence that binds a heat shock protein. Also included is a polypeptide comprising (a) a first peptide portion that comprises an &#x3b1;-helix-forming amino acid sequence that binds a heat shock protein; and (b) at least one second peptide portion comprising an antigenic amino acid sequence and/or an a-helix-stabilizing amino acid sequence that increases the interaction of the first peptide portion with the heat shock protein. The present application also includes compositions comprising the peptides and/or polypeptides of present application and uses of the peptides and/or polypeptides of the present application for fractionating substances relevant for discovery, research or clinical analysis from a biological sample and as therapeutics.

Polypeptides with affinity for heat shock proteins (HSPS) and HSP associated complexes (HACS) and their use in diagnosis and therapy

The present invention provides the use of nucleic acid sequences and/or amino acid sequences in the preparation of a vaccine for the protection of fish against infectious salmon anemia virus. Specifically, such vaccines contain at least one nucleic acid sequence which is derived from ISAV or synthetically prepared analogues thereof, or substantially homologous sequences. These nucleic acid sequences are transcripted and translated into peptide sequences which are incorporated into a vaccination strategy to induce and immune response to the surface antigens of ISAV and therefore ISAV itself. Therefore both the use of a vaccine against ISAV, and the incorporation of peptide sequences is herein described.

Nucleic acid and amino acid sequences of infectious salmon anaemia virus and their use as vaccines

The hsp60 gene from a strain ofhas been isolated and sequenced. The encoded protein is believed to be highly immunogenic, especially in fish, and also has utility as a non-specific adjuvant, and as an adjuvanting carrier for heterologous antigens.

HSP60 from arthrobacter

A vaccine based on livecells is useful in preventing piscirickettsiosis in fish.

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The hsp70 gene from anspecies has been isolated and sequenced. The encoded protein is believed to be highly immunogenic, especially in fish, and also has utility as a non-specific adjuvant, and as an adjuvanting carrier for heterologous antigens.

Vaccine against salmonid rickettsial septicaemia based on arthrobacter cells

Hsp60 from arthrobacter

The present invention provides the use of nucleic acid sequences and/or amino acid sequences in the preparation of a vaccine for the protection of fish against infectious salmon anaemia virus. Specifically, such vaccines contain at least one nucleic acid sequence which is derived from ISAV or synthetically prepared analogues thereof, or substantially homologous sequences. These nucleic acid sequences are transcripted and translated into peptide sequences which are incorporated into a vaccination strategy to induce and immune response to the surface antigens of ISAV and therefore ISAV itself. Therefore both the use of a vaccine against ISAV, and the incorporation of peptide sequences is herein described.

The present invention provides the use of nucleic acid sequences and/or amino acid sequences in the preparation of a vaccine for the protection of fish against infectious salmon anaemia virus. Specifically, such vaccines contain at least one nucleic acid sequence which is derived from ISAV or synthetically prepared analogues thereof, or substantially homologous sequences. These nucleic acid sequences are transcripted and translated into peptide sequences which are incorporated into a vaccination strategy to induce an immune response to the surface antigens of ISAV and therefore ISAV itself. Therefore both the use of a vaccine against ISAV, and the incorporation of peptide sequences, is herein described.

Nucleic acid and amino acid sequences of infectious salmon anaemia virus and their uses as vaccines

The invention provides and immune stimulating agent or vaccine directed tocomprising a live non-virulent culture of anstrain based on, derived from or substantially homologous with strain RSxII as deposited as ATCC 55921. The culture may be presented in lyophilized form with a sterile diluent.

Renibacterium salmoninarum vaccine

The invention provides an immune stimulating agent or vaccine directed to comprising a live non-virulent culture of an Arthrobacter strain based on, derived from or substantially homologous with strain RSxII as deposited as ATCC 55921. The culture may be presented in lyophilized form with a sterile diluent.

Growing community of inventors

Moncton, Canada

Steven Gareth Griffiths