Corixa Corporation

Infectious Disease Research Institute

Hdt Bio Corp.

Access To Advanced Health Institute

Glaxosmithkline Biologicals Sa

Inbios International, Inc.

Other

University of Chicago

Mogam Institute for Biomedical Research

Paxvax, Inc.

Lasys Corporation

Iasys Corporation

Infectious Diesease Research Institute

Infections Disease Research Institute

Steven G Reed

Davin C Dillon

Raymond L Houghton

Darrick Carter

Michael J Lodes

Yasir A Skeiky

Yasir A W Skeiky

Antonio Campos-Neto

Amit Praful Khandhar

Malcolm Duthie

Jesse Erasmus

Bryan J Berube

Thomas S Vedvick

Daniel R Twardzik

Rhea N Coler

Patricia Dianne McNeill

Mark R Alderson

John M Smith

Ajay Bhatia

Ronald C Hendrickson

John R Webb

Marc W Retter

Tony Nick Frudakis

Jiangchun Xu

Jeff Guderian

Yasuyuki Goto

Jennifer L Mitcham

Gregory C Ireton

Susan L Harlocker

Peter Probst

Paul R Sleath

Lynda Misher

Sylvie Bertholet

Gary R Fanger

Aijun Wang

Craig H Day

Yves Lobet

Michael D Kalos

Yuqiu Jiang

John A Stolk

Gordon E King

Christopher B Fox

Steven P Fling

Syamal Raychaudhuri

Paul Algate

Heather Secrist

Jacob Freeman Archer

Lars Peter Aksel Berglund

Tong Tong Wang

Eun Mi Kim

Samuel X Li

Martine Marchand

Raodoh Mohamath

Sung Jun Hong

Rima McLeod

Kamal El Bissati

Jeffery L Alexander

Hyo Jung Nam

Ernest J Mui

Ta Deng

Duck Hyang Shin

Malcolm S Duthie

Lucien Barnes V

Ryan M Kramer

Mary J Homer

Antonio Campos-Nero

Mark Brannon

Kang Il Yoo

Susan Baldwin

Shamgar Ben-Eliyahu

Pini Matzner

Tze Guan Tan

Hua Cong

William H Witola

Thomas Vedvick

V Lucien Barnes

The disclosure provides nanoemulsion compositions and methods of making and using thereof to deliver a bioactive agent such as a nucleic acid to a subject. The nanoemulsion composition comprises a hydrophobic core based on inorganic nanoparticles in a lipid nanoparticle that allows imaging as well as delivering nucleic acids. Methods of using these particles for treatment and vaccination are also provided.

Compositions and methods for delivery of RNA

The disclosure provides compositions, methods of treatment, and methods of making and using compositions to deliver a nucleic acid to a subject. Methods of using these compositions as a vaccine for treatment of an infectious disease are also provided.

RNA vaccines against infectious diseases

The present invention relates to compositions and fusion proteins containing at least twosp. antigens, and polynucleotides encoding such compositions and fusion proteins. The invention also relates to methods for their use in the treatment, prevention and/or diagnosis of tuberculosis infections.

Immunogenic compositions comprisingpolypeptides and fusions thereof

The disclosure provides compositions, methods of treatment, and methods of making and using compositions to deliver a nucleic acid to a subject. Methods of using the compositions as a COVID-19 vaccine for the treatment of a coronavirus infection are also provided.

SARS-CoV-2 RNA vaccine compositions and methods of use

Provided herein are dried compositions and methods for preparing such compositions for use in delivery of a nucleic acid to a subject. The dried composition may comprise a lipid carrier, wherein the lipid carrier is a nanoemulsion comprising a hydrophobic core, optionally one or more inorganic nanoparticles and one or more lipids, one or more nucleic acid, and at least one cryoprotectant. Methods of using these dried compositions for treatment are also provided.

Dried nanoparticle compositions

The present invention relates to compositions and fusion proteins containing at least twosp.) antigens, and polynucleotides encoding such compositions and fusion proteins. The invention also relates to methods for their use in the treatment, prevention and/or diagnosis of tuberculosis infections.

The invention provides for thermostable lyophilized formulations, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response, and methods of use thereof. The lyophilized formulations generally comprise an antigen and/or an adjuvant, a metabolizable oil, and a cake-forming excipient.

Single vial vaccine formulations

Compositions and methods for preventing, treating and detecting leprosy are disclosed. The compositions generally comprise polypeptides comprising one or moreantigens as well as polynucleotides encoding such polypeptides.

Vaccines comprisingpolypeptides for the prevention, treatment, and diagnosis of leprosy

Nucleic acid-small diameter and liquid core nanoparticle complexed compositions

Growing community of inventors

Bellevue, WA, United States of America

Steven G Reed