Wellstat Biocatalysis, LLC

Proteinix Corporation

Proteinix Company

Proteinex, Inc.

Steven F Roberts

John H Kenten

Aprile L Pilon

Alfonso Tramontano

Gerald L Lohnas

Disclosed are epitope-containing heat shock fusion proteins, DNA constructs encoding such fusion proteins, and methods of use. More specifically, disclosed are ubiquitin fusion proteins comprising ubiquitin fused to a plurality of identical or non-identical epitopes at specified locations.

Method for detection of specific antibodies using ubiquitin fusion proteins

The invention relates to novel compounds comprising a ubiquitination recognition element and a protein binding element. The invention also relates to the use of said compounds for modulating the level and/or activity of a target protein. The compounds are useful for the treatment of disease such as infections, inflammatory conditions, cancer and genetic diseases. The compounds are also useful as insecticides and herbicides.

Controlling protein levels in eucaryotic organisms

Method for reducing the level and/or activity of a target protein in a eukaryotic cell via activation of ubiquitination of the target protein wherein the cell is contacted with the compound having a ubiquitination recognition element covalently linked to a target protein binding element. The ubiquitination and recognition element can bind to either the E3 or E2 elements of the ubiquitination system and the target protein binding element is able to bind specifically to the target protein. The target protein binding element has a molecular weight of less than 30,000 and has a binding affinity for the target protein greater than 10M.

Ubiquitin fusion-based vaccine system

Heat shock fusion-based vaccine system

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Bethesda, MD, United States of America

Steven F Roberts